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Association of Obsessive-Compulsive Disorder with Substance Misuse: A Genetically Informative Population and Twin Study
Institute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
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2021 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 51, no 6, p. 751-752Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

It remains unclear whether individuals with obsessive-compulsive disorder (OCD) have an elevated risk of substance misuse, and whether OCD and substance misuse share genetic and/or environmental influences. We investigated the association between OCD and substance misuse in two samples. Sample 1 included all individuals born in Sweden 1932-1997 (n = 6,304,188). OCD was defined as an ICD-10 diagnosis in the patient register, and substance misuse as register-based substance use-related disorder, criminal conviction, or death. The sample was followed-up through the registers in 1997–2013. Sample 2 included participants of the Child and Adolescent Twin Study in Sweden with self-reported information on OCD-symptoms as well as alcohol and drug dependence symptoms at age 18 (n = 9231). We estimated the contribution of genetic and environmental influences to the covariance between OCD and substance misuse/dependence using data from full siblings and maternal half-siblings in sample 1, and monozygotic and dizygotic twins in sample 2. In sample 1, OCD was associated with an elevated risk of substance misuse (HR 3.84, 95% CI 3.74–3.95), and in sample 2, OCD-symptoms were associated with increased alcohol (b = 0.47 [0.41–0.55]) and drug (b = 0.69 [0.41–0.98]) dependence symptoms. Anxiety and depressive disorders did not explain the associations. In both samples, the associations between OCD and substance misuse were explained by genetic (56–68%) and non-shared environmental factors (32–44%). Genetic correlations ranged from 0.28 (0.24–0.32) to 0.31 (0.23–0.40). OCD was associated with an elevated risk of substance misuse, independently of the primary comorbidities, anxiety and depression. Genetic and non-shared environmental influences explained the association.

Place, publisher, year, edition, pages
Springer, 2021. Vol. 51, no 6, p. 751-752
Keywords [en]
OCD, Substance use, Twin study, Register-based, Longitudinal
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-95350ISI: 000709342700173OAI: oai:DiVA.org:oru-95350DiVA, id: diva2:1609810
Conference
51st Behavior Genetics Association Meeting (BGA 2021 Online), June 29, 2021
Funder
European CommissionAcademy of FinlandSwedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareAvailable from: 2021-11-09 Created: 2021-11-09 Last updated: 2021-11-09Bibliographically approved

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