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Cross-Species Comparisons of Nanoparticle Interactions with Innate Immune Systems: A Methodological Review
Institute of Biochemistry and Cell Biology, National Research Council, Napoli, Italy.
Department of Biology, Biotechnical Faculty, University of Liubljana, Ljubljana, Slovenia.
Institute for Biomedical Research and Innovation, National Research Council, Palermo, Italy.ORCID iD: 0000-0002-2403-7989
Institut Catalàde Nanosciència i Nanotecnologia (ICN2), Bellaterra, Barcelona, Spain.
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2021 (English)In: Nanomaterials, E-ISSN 2079-4991, Vol. 11, no 6, article id 1528Article, review/survey (Refereed) Published
Abstract [en]

Many components of the innate immune system are evolutionarily conserved and shared across many living organisms, from plants and invertebrates to humans. Therefore, these shared features can allow the comparative study of potentially dangerous substances, such as engineered nanoparticles (NPs). However, differences of methodology and procedure between diverse species and models make comparison of innate immune responses to NPs between organisms difficult in many cases. To this aim, this review provides an overview of suitable methods and assays that can be used to measure NP immune interactions across species in a multidisciplinary approach. The first part of this review describes the main innate immune defense characteristics of the selected models that can be associated to NPs exposure. In the second part, the different modes of exposure to NPs across models (considering isolated cells or whole organisms) and the main endpoints measured are discussed. In this synergistic perspective, we provide an overview of the current state of important cross-disciplinary immunological models to study NP-immune interactions and identify future research needs. As such, this paper could be used as a methodological reference point for future nano-immunosafety studies.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 11, no 6, article id 1528
Keywords [en]
environmental models, human cells, innate immunity, markers, NPs testing
National Category
Environmental Sciences Immunology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-95438DOI: 10.3390/nano11061528ISI: 000666800000001PubMedID: 34207693Scopus ID: 2-s2.0-85107404657OAI: oai:DiVA.org:oru-95438DiVA, id: diva2:1611439
Funder
EU, Horizon 2020, 671881Available from: 2021-11-15 Created: 2021-11-15 Last updated: 2023-05-16Bibliographically approved

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Alijagic, Andi

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