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Gene expression of leptin, leptin receptor isoforms and inflammatory cytokines in placentas of obese women: Associations to birth weight and fetal sex
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Obstetrics and Gynaecology.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-6045-4800
Örebro University, School of Medical Sciences. Örebro University Hospital. (Cinical Epidemiology and Biostatistic)ORCID iD: 0000-0002-3552-9153
Örebro University, School of Medical Sciences.
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2022 (English)In: Placenta, ISSN 0143-4004, E-ISSN 1532-3102, Vol. 117, p. 64-71Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Leptin signaling in placentas of obese women may influence fetal growth and may be dependent on fetal sex. The aim of this study was to investigate placental gene expression of leptin, its receptor and inflammatory cytokines in obese mothers in relation to offspring birth weight and sex.

METHODS: In total, 109 placental tissue samples from severely obese women (body mass index in first trimester ≥35 kg/m2) giving birth vaginally at term to a healthy child were included. Quantitative real-time PCR was used for the analysis of leptin (LEP), its receptor LEPR with two splice variants, interleukin (IL)1B, chemokine (C-X-C motif) ligand 8 (CXCL8), tumour necrosis factor (TNF), IL6, IL10, hypoxia-inducible factor 1-alpha (HIF1A) and insulin receptor (INSR). The subjects were divided into three groups based on LEP expression percentiles (<25th percentile; 25-75th percentile and >75th percentile).

RESULTS: A reverse U-shaped association between LEP expression and birth weight z-scores was found (R2 = 0.075, p = 0.005). Placental LEPRb expression was downregulated (p = 0.034) in those with highest LEP expression. Female infants had higher birth weight z-scores than males (0.58 (-1.49-2.88) vs 0.21 (-1.50-2.93), p = 0.020) and their placental LEPRb expression was upregulated (p = 0.047). The associations between expression of different genes differed by sex.

DISCUSSION: A reverse U-shaped relationship between placental LEP expression and offspring birth weight z-scores was found together with sexual dimorphism in LEPRb expression indicating a complex regulation of fetal growth by placental leptin signaling in maternal obesity.

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 117, p. 64-71
Keywords [en]
Cytokine, Gene expression, Infant birth weight, Leptin, Obesity, Placenta
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
URN: urn:nbn:se:oru:diva-95430DOI: 10.1016/j.placenta.2021.10.002ISI: 000742830300010PubMedID: 34773742Scopus ID: 2-s2.0-85118757784OAI: oai:DiVA.org:oru-95430DiVA, id: diva2:1611466
Note

Funding agencies:

Research Committee of Region Örebro County

Nyckelfonden, Örebro University Hospital

Available from: 2021-11-15 Created: 2021-11-15 Last updated: 2025-02-11Bibliographically approved

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Allbrand, MarianneEklund, DanielCao, YangNilsson, KerstinLodefalk, Maria

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