Inorganic phosphate and sulfate transport in S. cerevisiae
2016 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 892, p. 253-269Article in journal (Refereed) Published
Abstract [en]
Inorganic ions such as phosphate and sulfate are essential macronutrients required for a broad spectrum of cellular functions and their regulation. In a constantly fluctuating environment microorganisms have for their survival developed specific nutrient sensing and transport systems ensuring that the cellular nutrient needs are met. This chapter focuses on the S. cerevisiae plasma membrane localized transporters, of which some are strongly induced under conditions of nutrient scarcity and facilitate the active uptake of inorganic phosphate and sulfate. Recent advances in studying the properties of the high-affinity phosphate and sulfate transporters by means of site-directed mutagenesis have provided further insight into the molecular mechanisms contributing to substrate selectivity and transporter functionality of this important class of membrane transporters. © Springer International Publishing Switzerland 2016.
Place, publisher, year, edition, pages
Springer, 2016. Vol. 892, p. 253-269
Keywords [en]
Phosphate, Regulation, S. cerevisiae, Sulfate, Transport, carrier protein, Sul1 protein, Sul2 protein, unclassified drug, anion transport protein, PHO84 protein, S cerevisiae, PHO89 protein, S cerevisiae, phosphate proton cotransporter, Saccharomyces cerevisiae protein, sodium phosphate cotransporter 3, SUL1 protein, S cerevisiae, SUL2 protein, S cerevisiae, binding affinity, carbon utilization, cell membrane, fungal metabolism, gene expression, human, intracellular signaling, lipogenesis, molecular dynamics, nonhuman, priority journal, protein expression, proton transport, regulon, Saccharomyces cerevisiae, site directed mutagenesis, chemistry, enzyme specificity, gene expression regulation, genetics, ion transport, metabolism, signal transduction, structure activity relation, Anion Transport Proteins, Gene Expression Regulation, Fungal, Mutagenesis, Site-Directed, Phosphates, Proton-Phosphate Symporters, Saccharomyces cerevisiae Proteins, Sodium-Phosphate Cotransporter Proteins, Type III, Structure-Activity Relationship, Substrate Specificity, Sulfates
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-95544DOI: 10.1007/978-3-319-25304-6_10ISI: 000370774200010Scopus ID: 2-s2.0-84953262969OAI: oai:DiVA.org:oru-95544DiVA, id: diva2:1612863
2021-11-192021-11-192021-11-19Bibliographically approved