Functions connected to mood and emotion regulation are often reported as the most frequent and important functions of music, particularly during adolescence. However, less is known on how adolescents with intellectual disabilities (ID) use music for emotion regulation. The aim of this study was therefore to explore how adolescents with intellectual disabilities (n = 30) use music for mood regulation in comparison to adolescents without ID (n = 34). We assessed the seven mood-regulation strategies of the Music in Mood Regulation questionnaire, personality traits, mood, and a number of variables regarding music listening. The result showed that personality and mood were associated with the use of music for mood regulation and that adolescents with ID were less specific in their use of mood regulation strategies than adolescents without intellectual disabilities, even when adjusting for gender differences. In conclusion, the present study shows that personality traits in addition to mood is related to differences in usage of music for mood regulation among adolescents with and without intellectual disability. The study provides initial insights into the use of music and the relationships between personality, mood, and music in mood regulation in adolescents with intellectual disabilities.