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Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-1767-9297
Örebro University, School of Health Sciences.ORCID iD: 0000-0003-3793-335x
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-9831-0896
2021 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 10, no 22, article id 5316Article in journal (Refereed) Published
Abstract [en]

Systemic inflammation is believed to contribute to declining muscle health during aging. The present study aims to examine associations between indicators of muscle health and pro- and anti-inflammatory biomarkers in older men and women, while also considering the impacts of physical activity and protein intake. An assessment of skeletal muscle index (SMI) by bioelectrical impedance analysis, handgrip strength, and 5-sit-to-stand time, using standardized procedures, was conducted in a population of older men (n = 90) and women (n = 148) aged 65-70 years. The inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin (IL)-6, IL-10, IL-18, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α were assessed in blood samples. Data were analyzed and stratified according to biological sex using multiple linear regression models. In older women, SMI was inversely associated with the pro-inflammatory markers CRP (β = -0.372; p < 0.05), fibrinogen (β = -0.376; p < 0.05), and IL-6 (β = -0.369; p < 0.05). Importantly, these associations were independent of abdominal adiposity (waist circumference), protein intake, physical activity level, as well as any adherence to muscle strengthening guidelines (≥2 sessions/week). In contrast, no corresponding associations were observed in men. In conclusion, our findings indicate the detrimental influence of a pro-inflammatory environment on muscle health regardless of important lifestyle-related factors in older women. However, the lack of such associations in older men highlights the importance of considering biological sex when examining the complex interaction between the systemic inflammatory environment and muscle health.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 10, no 22, article id 5316
Keywords [en]
Aging, inflammatory biomarkers, muscle mass, muscle strength, muscle strengthening activities, obesity, physical activity, protein intake
National Category
Rheumatology and Autoimmunity Geriatrics
Identifiers
URN: urn:nbn:se:oru:diva-95657DOI: 10.3390/jcm10225316ISI: 000725211000001PubMedID: 34830593Scopus ID: 2-s2.0-85118957726OAI: oai:DiVA.org:oru-95657DiVA, id: diva2:1614995
Funder
European Commission, 727565Available from: 2021-11-29 Created: 2021-11-29 Last updated: 2022-08-26Bibliographically approved
In thesis
1. Chronic Systemic Inflammation, Body Composition and Physical Activity Behaviours in Older Adults
Open this publication in new window or tab >>Chronic Systemic Inflammation, Body Composition and Physical Activity Behaviours in Older Adults
2022 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Ageing is associated with a gradual physical decline accompanied by changes in body composition. The occurrence of a low-grade yet chronic state of systemic inflammation has gained interest for its potential consequences in the ageing process. Importantly, a physically active lifestyle may promote the maintenance of muscle mass, reduction in adipose tissue, and alleviate progression of a chronic pro-inflammatory state. 

The overall aim of this thesis was to explore relationships between biomarkers of systemic inflammation, body composition, and physical activity behaviours in community-dwelling older adults aged 65 to 70 years.

A main finding of the thesis is the existence of associations between body composition and systemic inflammation in older adults, where excess adipose tissue is adversely associated with levels of inflammatory biomarkers in older women. Inverse associations were also observed between muscle mass and levels of pro-inflammatory biomarkers in older women. This thesis also highlights sex-specific associations between systemic inflammation and physical activity behaviours. Longer time spent sedentary was also associated with higher levels of proinflammatory biomarkers in older women and lower level of antiinflammatory biomarkers in older men. Reallocating time spent in activities of lower intensities with higher intensities was associated with lower levels of pro-inflammatory biomarkers in older women. 

Overall, the findings of this thesis support efforts promoting physical activity at the expense of sedentary time in order to combat age-related systemic inflammation and metabolic risk in older adults.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2022. p. 101
Series
Örebro Studies in Sport Sciences, ISSN 1654-7535 ; 36
Keywords
Ageing, Exercise, Sedentary behaviour, Adipose tissue, Muscle mass, Muscle strength, Inflammatory biomarkers, Cardiorespiratory fitness, Metabolic health
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-96015 (URN)9789175294230 (ISBN)
Public defence
2022-03-04, Örebro universitet, Långhuset, Hörsal L2, Fakultetsgatan 1, Örebro, 09:00 (English)
Opponent
Supervisors
Available from: 2021-12-15 Created: 2021-12-15 Last updated: 2025-02-11Bibliographically approved

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Bergens, OscarNilsson, AndreasKadi, Fawzi

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