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Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption
Karolinska Instituted Unit of Integrative Toxicology, Institute of Environmental Medicine, Stockholm, Sweden.
Health Canada Tunney’s Pasture, Ottawa, Canada.
Health Canada Tunney’s Pasture, Ottawa, Canada.
Örebro University, School of Science and Technology. Stockholm University, Department of Environmental Science (ACES), Stockholm, Sweden. (MTM Research Centre)ORCID iD: 0000-0003-3403-093x
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2021 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 350, no Suppl., p. S163-S163Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

The toxicity of PCB-156 (2,3,3¢,4,4¢,5-hexachlorobiphenyl) was investigated in rats following subchronic dietary exposure. Groups of 10 male and 10 female Sprague-Dawley rats were administered PCB in the diet at 0, 0.01, 0.1, 1 or 10 ppm for 13 weeks. Results were analysed by group-wise comparison and benchmark dose-modelling. The latter revealed  ose-related decreases of final body weight, growth rate and thymus weight. Additionally, rats receiving PCB-156 showed dose-dependent weight increases of liver, lungs and kidneys. Biochemical changes included increases in liver EROD, PROD and UD-PGT enzymatic activities, as well as increases in uro-porphyrin. Retinoid (Vitamin A) quantification showed a clear and treatment-related reduction of the levels in the liver and lungs, as well as increased levels in the kidneys. A owest-observable-adverse-effect  level  (LOAEL) of 0.01 ppm was established, based on effects in the liver apolar retinoids concentration, corresponding to dietary exposure of 0.7 and 0.8 μg PCB-156/kg body weight per dayin male and female rats, respectively. Benchmark dose-modelling corroborated effects in the retinoid system, in both sexes, at even lower intake levels. The lower confidence limit (BMDL) for a 5% decrease in the concentration of liver apolar retinoids was 0.00086 (males) and 0.00068 ppm (fe-males), corresponding to a daily exposure of 0.06 μg PCB-156/kg body weight for both sexes. This BMDL5 is approximately 10-fold lower than the LOAEL for PCB-156. Based on the retinoid system’s susceptibility to PCB-156 exposure, we recommend effects on this system to be considered as critical for risk assessment of PCB-156 and other PCB congeners.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 350, no Suppl., p. S163-S163
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Pharmacology and Toxicology
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URN: urn:nbn:se:oru:diva-95637DOI: 10.1016/S0378-4274(21)00625-1ISI: 000714098000395OAI: oai:DiVA.org:oru-95637DiVA, id: diva2:1615203
Conference
56th Congress of the European Societies of Toxicology (EUROTOX 2021), Virtual Congress, September 27 – October 1, 2021
Available from: 2021-11-29 Created: 2021-11-29 Last updated: 2021-11-29Bibliographically approved

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Bergman, Åke

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