Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruptionShow others and affiliations
2021 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 350, no Suppl., p. S163-S163Article in journal, Meeting abstract (Other academic) Published
Abstract [en]
The toxicity of PCB-156 (2,3,3¢,4,4¢,5-hexachlorobiphenyl) was investigated in rats following subchronic dietary exposure. Groups of 10 male and 10 female Sprague-Dawley rats were administered PCB in the diet at 0, 0.01, 0.1, 1 or 10 ppm for 13 weeks. Results were analysed by group-wise comparison and benchmark dose-modelling. The latter revealed ose-related decreases of final body weight, growth rate and thymus weight. Additionally, rats receiving PCB-156 showed dose-dependent weight increases of liver, lungs and kidneys. Biochemical changes included increases in liver EROD, PROD and UD-PGT enzymatic activities, as well as increases in uro-porphyrin. Retinoid (Vitamin A) quantification showed a clear and treatment-related reduction of the levels in the liver and lungs, as well as increased levels in the kidneys. A owest-observable-adverse-effect level (LOAEL) of 0.01 ppm was established, based on effects in the liver apolar retinoids concentration, corresponding to dietary exposure of 0.7 and 0.8 μg PCB-156/kg body weight per dayin male and female rats, respectively. Benchmark dose-modelling corroborated effects in the retinoid system, in both sexes, at even lower intake levels. The lower confidence limit (BMDL) for a 5% decrease in the concentration of liver apolar retinoids was 0.00086 (males) and 0.00068 ppm (fe-males), corresponding to a daily exposure of 0.06 μg PCB-156/kg body weight for both sexes. This BMDL5 is approximately 10-fold lower than the LOAEL for PCB-156. Based on the retinoid system’s susceptibility to PCB-156 exposure, we recommend effects on this system to be considered as critical for risk assessment of PCB-156 and other PCB congeners.
Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 350, no Suppl., p. S163-S163
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-95637DOI: 10.1016/S0378-4274(21)00625-1ISI: 000714098000395OAI: oai:DiVA.org:oru-95637DiVA, id: diva2:1615203
Conference
56th Congress of the European Societies of Toxicology (EUROTOX 2021), Virtual Congress, September 27 – October 1, 2021
2021-11-292021-11-292021-11-29Bibliographically approved