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Carbamate pesticides exposure and delayed physical development at the age of seven: Evidence from the SMBCS study
School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China.
School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Key Lab of Health Technology, Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
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2022 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 160, article id 107076Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Carbamate pesticides are widely used in agriculture and cause widespread human exposure. The health effect of carbamates on physical development remains unclear. The current study aimed to explore the carbamate's health effect on physical development.

METHODS: Prenatal, 3-year-old, 7-year-old urinary carbofuranphenol concentration was measured by gas chromatography tandem mass spectrometry and adjusted by creatinine. Anthropometric indices were measured by standard method and z-score standardized. Generalized linear models (GLM) were using to assess associations between exposure measurements and anthropometric indices. The generalized estimate equation (GEE) was applied to analyze the association between multiperiod exposure and anthropometric indices, and time-interaction terms were used to exam health effect consistency of exposure in each period. Gender-stratified analysis were conducted according to results of gender-interaction terms to identify gender-specific effects.

RESULTS: The gender-interaction term of prenatal exposure with height z-score was significant (β = -0.057; 95% CI: -0.113, -0.001; p = 0.045). The 3-year-old carbofuranphenol level showed negative associations with weight z-score (β = -0.019; 95% CI: -0.038, -0.000; p = 0.040), height z-score (β = -0.015; 95% CI: -0.028, -0.001; p = 0.026), chest circumference (β = -0.086; 95% CI: -0.171, -0.001; p = 0.046), and waist circumference (β = -0.128; 95% CI: -0.230, -0.026; p = 0.014). No statistically significant trend was found for prenatal and 7-year-old carbofuranphenol levels. In GEEs, carbofuranphenol level was negatively associated with weight z-score (β = -0.103; 95% CI: -0.195, -0.011; p = 0.027), height z-score (β = -0.087; 95% CI: -0.152, -0.022; p = 0.008), and chest circumference (β = -0.472; 95% CI: -0.918, -0.026; p = 0.037). Boy's height z-score was inversely associated with carbamate exposure (β = -0.140; 95% CI: -0.227, -0.053; p = 0.001).

CONCLUSIONS: Prenatal and postnatal carbamate exposure may affect physical developmental process.

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 160, article id 107076
Keywords [en]
Birth cohort, Carbamate pesticides, Carbofuranphenol, Physical development
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-96355DOI: 10.1016/j.envint.2022.107076ISI: 000760318800002PubMedID: 34999346Scopus ID: 2-s2.0-85122266109OAI: oai:DiVA.org:oru-96355DiVA, id: diva2:1626327
Note

Funding agencies:

National Natural Science Foundation of China (NSFC) 82073501  

Shanghai 3Year Action Project GWV-10.1-XK11 GWV-10.1-XK12

Available from: 2022-01-11 Created: 2022-01-11 Last updated: 2022-03-29Bibliographically approved

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