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RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Infectious Diseases.ORCID iD: 0000-0001-8813-0384
Örebro University Hospital. Örebro University, School of Medical Sciences. Department of Medicine.ORCID iD: 0000-0003-1928-7518
Örebro University, School of Medical Sciences. Department of Anesthesiology and Intensive Care.
Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden.
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2022 (English)In: Infectious Diseases, ISSN 2374-4235, E-ISSN 2374-4243, Vol. 54, no 6, p. 431-440Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: COVID-19 has a most variable prognosis. Several risk factors for an unfavourable outcome have been identified including extensive lung involvement on chest CT and high viral load estimated by RT-PCR cycle threshold (Ct) values. We investigated Ct value for outcome prediction, relation between Ct value and extent of lung involvement on chest CT and the combination of Ct value and chest CT lung involvement to predict outcome in COVID-19.

METHODS: Population-based retrospective study on all patients (n = 286) hospitalised for COVID-19 in Örebro Region, Sweden, between 1 March and 31 August 2020. Nasopharyngeal samples and chest CT at hospital admission were evaluated in relation to outcome of COVID-19.

RESULTS: Both Ct value and chest CT lung involvement were independently associated with risk for ICU admission or death. Lung involvement was superior as a single parameter, but addition of Ct value increased the prediction performance. Ct value was especially useful to identify patients with high risk for severe disease despite limited lung involvement.

CONCLUSIONS: The addition of RT-PCR Ct value to the assessment of lung involvement on chest CT adds valuable prognostic information in COVID-19. We believe that this information can be used to support clinical decision-making when managing COVID-19 patients.

Place, publisher, year, edition, pages
Taylor & Francis, 2022. Vol. 54, no 6, p. 431-440
Keywords [en]
COVID-19, Sars-cov-2, computed tomography, cycle threshold, outcome
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-97231DOI: 10.1080/23744235.2022.2035428ISI: 000751555300001PubMedID: 35114897Scopus ID: 2-s2.0-85124316137OAI: oai:DiVA.org:oru-97231DiVA, id: diva2:1635459
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Region Örebro CountyAvailable from: 2022-02-07 Created: 2022-02-07 Last updated: 2024-01-10Bibliographically approved

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Ingberg, EdvinAhlstrand, ErikCajander, PerSundqvist, MartinLidén, MatsCajander, Sara

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