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Osteopontin: another piece in the systemic lupus erythematosus immunopathology puzzle
Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara, Mexico; UDG-CA-703, Inmunología y Reumatología, Guadalajara, Spain.
Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara, Mexico; Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Clínicas Médicas, Guadalajara, Mexico.
Univ Guadalajara, Ctr Univ Tonala, Div Ciencias Salud, Dept Ciencias Biomed, Tonala, Mexico; Universidad de Guadalajara, Centro Universitario de Tonalá, Departamento de Ciencias Biomédicas, División de Ciencias de la Salud, Tonalá, Mexico.
Örebro University, School of Medical Sciences. Örebro University Hospital. Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Molecular y Genómica, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), Guadalajara, Mexico; Department of Cardiothoracic and Vascular Surgey, Örebro University Hospital, Region Örebro County, Örebro, Sweden.ORCID iD: 0000-0002-6892-2680
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2022 (English)In: Clinical and Experimental Rheumatology, ISSN 0392-856X, E-ISSN 1593-098X, Vol. 40, no 1, p. 173-182Article, review/survey (Refereed) Published
Abstract [en]

Osteopontin (OPN) is a phosphoglycoprotein involved in bone remodelling, wound healing, cell adhesion, tissue remodelling, and immune response that is distributed widely in normal adult tissues. OPN biological activity is regulated by thrombin and matrix metalloproteinases (MMPs) cleavage, where the full-length (OPN-FL) protein and the cleaved OPN-N are associated with autoimmune diseases such as systemic lupus erythematosus (SLE). OPN overexpression has been associated with a predisposition to SLE and bad prognosis since OPN could mediate a sustained polyclonal B cell activation that besides to intracellular OPN (iOPN) form, promote the T follicular helper (T-FH) cells and enhance anti-nuclear antibody production. Currently, the role of OPN in lupus nephritis (LN) has been reported and extensively studied; however, no data are available about the potential mechanism of OPN in neuropsychiatric SLE (NPSLE). In this review, we highlighted the contribution of OPN and iOPN in LN and NPSLE immunopathology.

Place, publisher, year, edition, pages
CLINICAL & EXPER RHEUMATOLOGY , 2022. Vol. 40, no 1, p. 173-182
Keywords [en]
osteopontin, systemic lupus erythematosus, lupus nephritis, neuropsychiatric SLE
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:oru:diva-97365DOI: 10.55563/clinexprheumatol/x2g7rpISI: 000749536500024PubMedID: 34128791Scopus ID: 2-s2.0-85123879574OAI: oai:DiVA.org:oru-97365DiVA, id: diva2:1636233
Available from: 2022-02-09 Created: 2022-02-09 Last updated: 2022-11-15Bibliographically approved

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