Modern neonatal care is becoming more and more family-centered with increased possibilities for parents to stay at the unit all day round. There is a growing awareness that parents also are important providers of care to their hospitalized infants, not only being visitors at the unit. This care that parents or other caregivers can provide, includes pain management.There are several pain-relieving interventions that can be applied by parents, for example breastfeeding, skin-to-skin contact, lullaby singing and facilitated tucking. There is also evidence that parents want to be involved in active pain management for their newborn infants. This role includes advocating for their child and interacting with the staff in assessment and pain alleviation.Despite this, parent-driven interventions are seldom recommended in pain management guidelines and the role of caregivers in infant pain management is not promoted. In this workshop we argue for a better uptake of caregivers as a resource for infant pain management, where the meaning of PCA is extended from Patient-Controlled Analgesia to Parent-Controlled Analgesia. We will present the latest evidence about the efficacy of caregiver-driven interventions and give example of on-going research.