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The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)
Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Molecular Disease & Diagnosis Division, Infinity Biochemistry Pvt. Ltd, Sajjad Abad, Chattabal, Srinagar, Kashmir, India; Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Kashmir, India.
Molecular Disease & Diagnosis Division, Infinity Biochemistry Pvt. Ltd, Sajjad Abad, Chattabal, Srinagar, Kashmir, India; Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Kashmir, India.
Molecular Disease & Diagnosis Division, Infinity Biochemistry Pvt. Ltd, Sajjad Abad, Chattabal, Srinagar, Kashmir, India; Department of Biochemistry, Government Medical College, Karan Nagar, Srinagar, Kashmir, India.
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2022 (English)In: Journal of Immunology Research, ISSN 2314-8861, E-ISSN 2314-7156, Vol. 2022, article id 2054431Article, review/survey (Refereed) Published
Abstract [en]

Interleukins (ILs)-which are important members of cytokines-consist of a vast group of molecules, including a wide range of immune mediators that contribute to the immunological responses of many cells and tissues. ILs are immune-glycoproteins, which directly contribute to the growth, activation, adhesion, differentiation, migration, proliferation, and maturation of immune cells; and subsequently, they are involved in the pro and anti-inflammatory responses of the body, by their interaction with a wide range of receptors. Due to the importance of immune system in different organisms, the genes belonging to immune elements, such as ILs, have been studied vigorously. The results of recent investigations showed that the genes pertaining to the immune system undergo progressive evolution with a constant rate. The occurrence of any mutation or polymorphism in IL genes may result in substantial changes in their biology and function and may be associated with a wide range of diseases and disorders. Among these abnormalities, single nucleotide polymorphisms (SNPs) can represent as important disruptive factors. The present review aims at concisely summarizing the current knowledge available on the occurrence, properties, role, and biological consequences of SNPs within the IL-1 family members.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2022. Vol. 2022, article id 2054431
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Infectious Medicine Immunology
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URN: urn:nbn:se:oru:diva-98479DOI: 10.1155/2022/2054431ISI: 000838063900001PubMedID: 35378905Scopus ID: 2-s2.0-85127514281OAI: oai:DiVA.org:oru-98479DiVA, id: diva2:1650429
Note

Funding agencies:

Portuguese Foundation for Science and Technology European Commission DL 57/2016  

Ministry of Health, Italy SG-2018-12365432 

Hungarian Academy of Sciences BO/00144/20/5

New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund UNKP-21-5-540-SZTE

ESCMID's "30 under 30" Award

Available from: 2022-04-07 Created: 2022-04-07 Last updated: 2022-08-24Bibliographically approved

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Magnusson, Peter

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