Associations between mental and physical conditions in children and adolescents: an umbrella reviewServicio Navarro de Salud-Osasunbidea, Navarra, Spain.
Faculty of Education and Psychology, University of Navarra, Pamplona, Spain.
Faculty of Education and Psychology, University of Navarra, Pamplona, Spain.
Innovation in Mental and Physical Health and Clinical Treatment (IMPACT) Strategic Research Centre, Deakin University, Geelong, VIC, Australia.
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
Early Psychosis, Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London, UK; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
The Zucker Hillside Hospital, Division of Psychiatry Research, Northwell Health, Glen Oaks, New York, New York, USA; Department of Psychiatry and Molecular Medicine, The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, New York, USA; Department of Child and Adolescent Psychiatry, Charité Universitäts medizin, Berlin, Germany.
Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK; Solent NHS Trust, Southampton, UK; Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, UK; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York City, New York, US.
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2022 (English)In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 137, article id 104662Article, review/survey (Refereed) Published
Abstract [en]
We mapped the evidence on the type and strength of associations between a broad range of mental and physical conditions in children and adolescents, by carrying out an umbrella review, i.e., a quantitative synthesis of previous systematic reviews and meta-analyses. We also assessed to which extent the links between mental and physical conditions vary across disorders or, by contrast, are transdiagnostic. Based on a pre-established protocol, we retained 45 studies, encompassing around 12.5 million of participants. In analyses limited to the most rigorous estimates, we found evidence for the following associations: ADHD-asthma, ADHD-obesity, and depression-asthma. A transdiagnostic association was confirmed between asthma and anxiety/ASD/depression/bipolar disorder, between obesity and ADHD/ASD/depression, and between dermatitis and ASD/ADHD. We conclude that obesity and allergic conditions are likely to be associated with mental disorders in children and adolescents. Our results can help clinicians explore potential links between mental and physical conditions in children/adolescent and provide a road map for future studies aimed at shading light on the underlying factors.
Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 137, article id 104662
Keywords [en]
Mental, Physical, Transdiagnostic, Umbrella review, meta-analysis
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-98644DOI: 10.1016/j.neubiorev.2022.104662ISI: 000821893800025PubMedID: 35427644Scopus ID: 2-s2.0-85128308036OAI: oai:DiVA.org:oru-98644DiVA, id: diva2:1653372
Note
Funding agencies:
Spanish Government CAS19/00249
Medical Association of Navarre
European Social Fund (ESF)
Spanish Government 2017-22060
NIHR Oxford Cognitive Health Clinical Research Facility
NIHR Research Professorship RP-2017-08-ST2-006
NIHR Oxford and Thames Valley Applied Research Collaboration
NIHR Oxford Health Biomedical Research Centre BRC-1215-20005
2022-04-212022-04-212022-07-29Bibliographically approved