Axonal injury in asymptomatic individuals preceding onset of multiple sclerosisShow others and affiliations
2022 (English)In: Annals of Clinical and Translational Neurology, E-ISSN 2328-9503, Vol. 9, no 6, p. 882-887Article in journal (Refereed) Published
Abstract [en]
Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case-control study, blood samples from 519 presymptomatic persons (age range 4-39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0-5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5-10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.
Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 9, no 6, p. 882-887
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-98852DOI: 10.1002/acn3.51568ISI: 000789844900001PubMedID: 35502756Scopus ID: 2-s2.0-85129266300OAI: oai:DiVA.org:oru-98852DiVA, id: diva2:1655992
Funder
Swedish Research Council, 2018-02532 2017-00915EU, European Research Council, 681712Stiftelsen Gamla TjänarinnorThe Swedish Brain Foundation, FO2019-0228 FO2017-0243Alzheimerfonden, AF-742881
Note
Funding agencies:
Swedish Government ALFGBG-772071 ALFGBG-715986
Research Foundation of the Gothenburg MS Society
Bjornsson Research Foundation, Gothenburg, Sweden
Gothenburg Society of Medicine
Swedish State Support for Clinical Research ALFGBG-720931
Alzheimer Drug Discovery Foundation (ADDF), USA 201809-2016862 RDAPB-201809-2016615
AD Strategic Fund
Alzheimer's Association ADSF-21-831376-C ADSF-21-831381-C ADSF-21-831377-C
Olav Thon Foundation
Erling-Persson Family Foundation
SKA South Africa 860197
European Union Joint Program for Neurodegenerative Disorders JPND2021-00694 JPND2019-466-236
UK Dementia Research Institute at UCL
Swedish County Councils, the ALFagreement ALFGBG-715986
United States Department of Health & Human Services National Institutes of Health (NIH) - USA 1R01AG068398-01
Alzheimer's Association 2021 Zenith Award ZEN-21-848495
2022-05-042022-05-042023-12-08Bibliographically approved