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Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Dahlgren's Academy, University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Centre for Neurodegenerative Diseases, Hong Kong, China.
Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden.
Department of Neurology, Skåne University Hospital, Lund, Sweden; Department of Clinical Sciences, Lund University, Lund, Sweden.
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2022 (English)In: Annals of Clinical and Translational Neurology, E-ISSN 2328-9503, Vol. 9, no 6, p. 882-887Article in journal (Refereed) Published
Abstract [en]

Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case-control study, blood samples from 519 presymptomatic persons (age range 4-39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre-MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0-5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5-10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 9, no 6, p. 882-887
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-98852DOI: 10.1002/acn3.51568ISI: 000789844900001PubMedID: 35502756Scopus ID: 2-s2.0-85129266300OAI: oai:DiVA.org:oru-98852DiVA, id: diva2:1655992
Funder
Swedish Research Council, 2018-02532 2017-00915EU, European Research Council, 681712Stiftelsen Gamla TjänarinnorThe Swedish Brain Foundation, FO2019-0228 FO2017-0243Alzheimerfonden, AF-742881
Note

Funding agencies:

Swedish Government ALFGBG-772071 ALFGBG-715986 

Research Foundation of the Gothenburg MS Society

Bjornsson Research Foundation, Gothenburg, Sweden

Gothenburg Society of Medicine

Swedish State Support for Clinical Research ALFGBG-720931

Alzheimer Drug Discovery Foundation (ADDF), USA 201809-2016862 RDAPB-201809-2016615 

AD Strategic Fund

Alzheimer's Association ADSF-21-831376-C ADSF-21-831381-C  ADSF-21-831377-C 

Olav Thon Foundation

Erling-Persson Family Foundation

SKA South Africa 860197  

European Union Joint Program for Neurodegenerative Disorders JPND2021-00694 JPND2019-466-236 

UK Dementia Research Institute at UCL

Swedish County Councils, the ALFagreement ALFGBG-715986

United States Department of Health & Human Services National Institutes of Health (NIH) - USA 1R01AG068398-01  

Alzheimer's Association 2021 Zenith Award ZEN-21-848495

Available from: 2022-05-04 Created: 2022-05-04 Last updated: 2023-12-08Bibliographically approved

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