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Brain damage markers neuron-specific enolase (NSE) and S100B in serum in children with Lyme neuroborreliosis-detection and evaluation as prognostic biomarkers for clinical outcome
Department of Clinical Science, Intervention and Technology – CLINTEC, Huddinge, Stockholm, Sweden; Department of Pediatric Infectious Diseases, Astrid Lindgren’s Children’s Hospital, Solna, Stockholm, Sweden.ORCID iD: 0000-0002-3258-427X
Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden; National Reference Laboratory for Borrelia and Other Tick-Borne Bacteria, Division of Clinical Microbiology, Laboratory Medicine, Region Jönköping County, Linköping University, Linköping, Sweden; Department of Clinical Microbiology in Linköping, Linköping University, Linköping, Sweden.ORCID iD: 0000-0002-9315-8901
Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden; Department of Clinical Chemistry and Transfusion Medicine, Region Kalmar County, Kalmar, Sweden.
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2022 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 41, no 7, p. 1051-1057Article in journal (Refereed) Published
Abstract [en]

Lyme borreliosis (LB) is the most common tick-borne infection in Europe, with Lyme neuroborreliosis (LNB) its second most frequent clinical manifestation. Prognostic factors for clinical outcomes in LNB have not been identified. Elevated serum levels of the brain damage markers neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) have been associated with poor clinical outcomes in other disorders of the central nervous system. The aim of this study is to assess NSE and S100B in serum as prognostic biomarkers for clinical outcomes in paediatric LNB patients. Children evaluated for LNB (n= 121) in Sweden were prospectively included during 2010-2014, serum samples were collected on admission, and all children underwent a 2-month follow-up. Patients with pleocytosis and anti-Borrelia antibodies in cerebrospinal fluid (CSF) were classified as having LNB (n= 61). Controls were age- and gender-matched non-LNB patients (n= 60). NSE was elevated in 38/61 (62%) LNB patients and in 31/60 (52%) controls. S100B was elevated in 3/60 (5%) LNB patients and 0/59 (0%) controls. NSE and S100B concentrations did not differ significantly when comparing LNB patients with controls. No differences were found in the concentrations when comparing the clinical recovery of LNB patients at the 2-month follow-up. NSE was detectable in the majority of LNB patients and controls, whereas S100B was detectable in only a few LNB patients and no controls. NSE and S100B in serum cannot be recommended as prognostic biomarkers for clinical outcomes in children with LNB.

Place, publisher, year, edition, pages
Springer, 2022. Vol. 41, no 7, p. 1051-1057
Keywords [en]
Lyme neuroborreliosis, S100B, NSE, Clinical outcome, Brain damage markers, Biomarkers
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-99598DOI: 10.1007/s10096-022-04460-1ISI: 000806123400001PubMedID: 35665437Scopus ID: 2-s2.0-85131526907OAI: oai:DiVA.org:oru-99598DiVA, id: diva2:1669817
Funder
Karolinska InstituteSwedish Society of Medicine, SLS498901 SLS-93191
Note

Funding agencies:

Regional Research Council Uppsala-Orebro RFR-226161 RFR-462701 

Center for Clinical Research Dalarna-Uppsala University CKFUU-105141 CKFUU374651 CKFUU-566761 

Available from: 2022-06-15 Created: 2022-06-15 Last updated: 2022-08-22Bibliographically approved

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Skogman, Barbro H

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