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Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finland.
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
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2022 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 65, no 9, p. 1534-1540Article in journal (Refereed) Published
Abstract [en]

AIMS/HYPOTHESIS: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes.

METHODS: Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and/or who tested positive for multiple islet autoantibodies (n = 43) were compared with control individuals (n = 79) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis.

RESULTS: No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate <0.05.

CONCLUSIONS/INTERPRETATION: Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset.

Place, publisher, year, edition, pages
Springer, 2022. Vol. 65, no 9, p. 1534-1540
Keywords [en]
Bisulphite sequencing, DNA methylation, Epigenomics, Follow-up study, Type 1 diabetes, Umbilical cord blood
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-99651DOI: 10.1007/s00125-022-05726-1ISI: 000812577400001PubMedID: 35716175Scopus ID: 2-s2.0-85132162740OAI: oai:DiVA.org:oru-99651DiVA, id: diva2:1673021
Funder
Novo NordiskAcademy of Finland, 340231 292335 294337 319280 31444 329277 331790 296801 310561 314443 329278 335434 335611EU, European Research Council, 677943EU, Horizon 2020, 675395
Note

Funding agencies:

University of Turku (UTU)

InFLAMES Flagship Programme of the Academy of Finland 337530

Juvenile Diabetes Research Foundation 1-SRA-2016-342-M-R 1-SRA-2019-732-M-B

Finnish Diabetes Foundation

Special Research Funds for University Hospitals in Finland

Business Finland

Sigrid Juselius Foundation

Jane and Aatos Erkko Foundation

Finnish Cancer Foundation

Turku University Central Hospital

Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) 250114 292482 

European Foundation for the Study of Diabetes

Pediatric Research Foundation

Turku University Hospital Special Governmental Grants

Biocenter Finland

ELIXIR Finland

Turku Doctoral Programme of Molecular Medicine

Finnish Cultural Foundation

Finnish IT center for science 

Kyllikki and Uolevi Lehikoinen Foundation

 

Available from: 2022-06-20 Created: 2022-06-20 Last updated: 2022-08-22Bibliographically approved

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Oresic, Matej

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