Biomarker Associations in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid HemorrhageShow others and affiliations
2022 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 23, no 15, article id 8789
Article in journal (Refereed) Published
Abstract [en]
The prognosis for patients with aneurysmal subarachnoid hemorrhage (aSAH) is heavily influenced by the development of delayed cerebral ischemia (DCI), but the adequate and effective therapy of DCI to this day has not been resolved. Multiplex serum biomarker studies may help to understand the pathophysiological processes underlying DCI. Samples were collected from patients with aSAH at two time points: (1) 24 h (Day 1) and (2) 5-7 days after ictus. Serum concentrations of eotaxin, FGF-2, FLT-3L, CX3CL1, Il-1b, IL-4, IP-10, MCP3, and MIP-1b were determined using a customized MILLIPLEX Human Cytokine/Chemokine/Growth Factor Panel A multiplex assay. The functional outcome was defined by the modified Rankin scale (favorable: 0-2, unfavorable: 3-6) measured on the 30th day after aSAH. One-hundred and twelve patients with aSAH were included in this study. The median level of CX3CL1 and MCP-3 measured on Days 5-7 were significantly higher in patients with DCI compared with those without DCI (CX3CL1: with DCI: 110.5 pg/mL, IQR: 82-201 vs. without DCI: 82.6, 58-119, p = 0.036; and MCP-3: with DCI: 22 pg/mL (0-32) vs. without DCI: 0 (0-11), p < 0.001). IP-10, MCP-3, and MIP-1b also showed significant associations with the functional outcome after aSAH. MCP-3 and CX3CL1 may play a role in the pathophysiology of DCI.
Place, publisher, year, edition, pages
MDPI, 2022. Vol. 23, no 15, article id 8789
Keywords [en]
CX3CL1, IP-10, MCP-3, aneurysmal subarachnoid hemorrhage, delayed cerebral ischemia, functional outcome
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-100659DOI: 10.3390/ijms23158789ISI: 000839056900001PubMedID: 35955921Scopus ID: 2-s2.0-85137119264OAI: oai:DiVA.org:oru-100659DiVA, id: diva2:1687658
Note
Funding agency:
(AOK-KK Kollaboracios Alap (AOK-TANDEM)) from University of Pecs, Hungary
2022-08-162022-08-162024-09-04Bibliographically approved