To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study
Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville FL, United States.
Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville FL, United States.
Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville FL, United States.
Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville FL, United States.
Show others and affiliations
2022 (English)In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988, Vol. 12, article id 920735Article in journal (Refereed) Published
Abstract [en]

Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 +/- 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine core microbes with prevalence differences and seven differentially abundant bacteria between fCD infants and controls. The differences were validated using 100 separate, iterative permutations of matched controls, which suggests the bacterial signatures are significant in fCD even when accounting for the inherent variability in a general population. This work is the first to our knowledge to demonstrate that gut microbial differences in prevalence and abundance exist in infants aged one year up to 19 years before a diagnosis of CD in a general population.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2022. Vol. 12, article id 920735
Keywords [en]
celiac disease, autoimmunity, human leucocyte antigen, infant, gut microbiome
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-100822DOI: 10.3389/fcimb.2022.920735ISI: 000838091700001PubMedID: 35959362Scopus ID: 2-s2.0-85136340295OAI: oai:DiVA.org:oru-100822DiVA, id: diva2:1689942
Funder
Swedish Child Diabetes FoundationForte, Swedish Research Council for Health, Working Life and Welfare, FAS2004-1775Swedish Research Council, K2005-72 x -11242-11A K2008-69 x -2082601-4 K2008-69 x -20826-01-4Region ÖstergötlandLinköpings universitet
Note

Funding agencies:

Medical Research Council of Southeast Sweden (FORSS)

JDRF Wallenberg Foundation K 9899D-12813-01A

Joanna Cocozza Foundation

Östgota Brandstodsbolag

Available from: 2022-08-24 Created: 2022-08-24 Last updated: 2023-12-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Ludvigsson, Jonas F.

Search in DiVA

By author/editor
Ludvigsson, Jonas F.
By organisation
School of Medical SciencesÖrebro University Hospital
In the same journal
Frontiers in Cellular and Infection Microbiology
Immunology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 17 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf