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Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes
School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
School of Public Health / MOE Key Laboratory of Public Health Safety / NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China.
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2022 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 215, no Part 1, article id 114226Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear.

OBJECTIVE: To explore the association between prenatal triclosan exposure and birth outcomes.

METHODS: Based on 726 mother-child pairs from the Sheyang Mini Birth Cohort Study (SMBCS), we used the available (published) data of triclosan in maternal urines, the hormones including thyroid-related hormones, gonadal hormones in cord blood, and adipokines, trimethylamine-N-oxide (TMAO) and its precursors in cord blood to explore possible health effects of triclosan on birth outcomes through assessing different hormones and parameters, using Bayesian mediation analysis.

RESULTS: Maternal triclosan exposure was associated with ponderal index (β = 0.317) and head circumference (β = -0.172) in generalized linear models. In Bayesian mediation analysis of PI model, estradiol (β = 0.806) and trimethylamine (TMA, β = 0.164) showed positive mediation effects, while total thyroxine (TT4, β = -0.302), leptin (β = -2.023) and TMAO (β = -0.110) showed negative mediation effects. As for model of head circumference, positive mediation effects were observed in free thyroxine (FT4, β = 0.493), TMA (β = 0.178), and TMAO (β = 0.683), negative mediation effects were observed in TT4 (β = -0.231), testosterone (β = -0.331), estradiol (β = -1.153), leptin (β = -2.361), choline (β = -0.169), betaine (β = -0.104), acetyl-L-carnitine (β = -0.773).

CONCLUSION: The results indicated triclosan can affect intrauterine growth by interfering thyroid-related hormones, gonadal hormones, adipokines, TMAO and its precursors.

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 215, no Part 1, article id 114226
Keywords [en]
Bayesian mediation analysis, Birth outcome, Endocrine disruptor, Mediation effect, Triclosan
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-101075DOI: 10.1016/j.envres.2022.114226ISI: 000860552700008PubMedID: 36049513Scopus ID: 2-s2.0-85137620956OAI: oai:DiVA.org:oru-101075DiVA, id: diva2:1692845
Note

Funding agencies:

Shanghai 3 -Year Action Project GWV-10.1-XK11 GWV-10.1-XK12 

National Natural Science Foundation of China (NSFC) 82073501 81611130087 

Available from: 2022-09-05 Created: 2022-09-05 Last updated: 2022-10-05Bibliographically approved

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