Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout ratsShow others and affiliations
2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 15454
Article in journal (Refereed) Published
Abstract [en]
Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain fatty acids (SCFAs), have been shown to positively influence lipid profile and biomarkers in the gut and brain. This study examined whether MB and MV in high-fat diets, affected microbiota composition and gut-blood-brain markers in apolipoprotein E deficient (ApoE-/-) rats, a model for studies of lipid-associated disorders, and neurodegenerative processes in Alzheimer's disease (AD). ApoE-/- rats fed MB and MV increased Tenericutes and the brain neurotransmitter γ-aminobutyric acid (GABA), while the blood stress hormone corticosterone decreased compared to control rats. Only rats that received MB showed a significant increase in cholic acid and Adlercreutzia in the caecum. In rats fed MV, the decrease of Proteobacteria was associated with decreased corticosterone levels. Conclusively, dietary supplementation of SCFA glycerol esters can modulate gut-blood-brain markers and alter gut microbiota composition in ApoE-/- rats, suggesting that SCFAs also could counteract lipid disorders-related diseases.
Place, publisher, year, edition, pages
Nature Publishing Group, 2022. Vol. 12, no 1, article id 15454
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-101419DOI: 10.1038/s41598-022-19502-zISI: 000853934100067PubMedID: 36104381Scopus ID: 2-s2.0-85137940789OAI: oai:DiVA.org:oru-101419DiVA, id: diva2:1698397
Note
Funding agencies:
Mekong 1000 Project (Viet Nam)
Perstorp AB (Sweden)
Johanna Andersson Foundation 92900
Albert Påhlsson Foundation FB2019-0306
2022-09-232022-09-232022-09-29Bibliographically approved