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Monobutyrin and monovalerin improve gut-blood-brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats
Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.
Laboratory of Nutritional Biochemistry, Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan; Department of Gastroenterology and Hepatology, Fujita Health University, Aichi, Japan.
Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.
Örebro University, School of Science and Technology. (MTM Research Centre)
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 15454Article in journal (Refereed) Published
Abstract [en]

Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain fatty acids (SCFAs), have been shown to positively influence lipid profile and biomarkers in the gut and brain. This study examined whether MB and MV in high-fat diets, affected microbiota composition and gut-blood-brain markers in apolipoprotein E deficient (ApoE-/-) rats, a model for studies of lipid-associated disorders, and neurodegenerative processes in Alzheimer's disease (AD). ApoE-/- rats fed MB and MV increased Tenericutes and the brain neurotransmitter γ-aminobutyric acid (GABA), while the blood stress hormone corticosterone decreased compared to control rats. Only rats that received MB showed a significant increase in cholic acid and Adlercreutzia in the caecum. In rats fed MV, the decrease of Proteobacteria was associated with decreased corticosterone levels. Conclusively, dietary supplementation of SCFA glycerol esters can modulate gut-blood-brain markers and alter gut microbiota composition in ApoE-/- rats, suggesting that SCFAs also could counteract lipid disorders-related diseases.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022. Vol. 12, no 1, article id 15454
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Nutrition and Dietetics
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URN: urn:nbn:se:oru:diva-101419DOI: 10.1038/s41598-022-19502-zISI: 000853934100067PubMedID: 36104381Scopus ID: 2-s2.0-85137940789OAI: oai:DiVA.org:oru-101419DiVA, id: diva2:1698397
Note

Funding agencies:

Mekong 1000 Project (Viet Nam)

Perstorp AB (Sweden)

Johanna Andersson Foundation 92900

Albert Påhlsson Foundation FB2019-0306

Available from: 2022-09-23 Created: 2022-09-23 Last updated: 2022-09-29Bibliographically approved

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Ghaffarzadegan, Tannaz

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