To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Colorectal Cancer in Childhood-onset Inflammatory Bowel Disease: A Scandinavian Register-based Cohort Study, 1969-2017
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.ORCID iD: 0000-0003-1024-5602
Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark; Department of Surgery, Randers Regional Hospital, Randers, Denmark.
Show others and affiliations
2022 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 75, no 4, p. 480-484Article in journal (Refereed) Published
Abstract [en]

Through linkage of data from Danish and Swedish national registers we identified 6937 patients with childhood (<18 years)-onset Crohn disease (CD), 8514 patients with childhood-onset ulcerative colitis (UC) and up to 10 times as many matched (sex, age, residence) reference individuals 1969-2017. During follow-up to a median age of 27 (interquartile range = 21-39) years, 25 (0.36%) CD patients were diagnosed with colorectal cancer (CRC) versus 43 (0.06%) reference individuals, and 113 (1.33%) UC patients versus 45 (0.05%) reference individuals. The hazard ratio (HR) for CRC was 6.46 (95% CI = 3.95-10.6) in CD and 32.5 (95% CI = 23.0-45.9) in UC and increased with decreasing age at diagnosis. The HR for CRC was increased for all phenotypes, but with higher estimates for colonic CD [17.9 (95% CI = 7.43-43.3)] and UC with extensive/pancolitis [36.3 (95% CI = 22.8-57.8)]. The relative risk of CRC was increased for all phenotypes of childhood-onset inflammatory bowel disease. Age at onset may be considered an additional risk factor when implementing surveillance programs.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2022. Vol. 75, no 4, p. 480-484
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-101429DOI: 10.1097/MPG.0000000000003574ISI: 000855495300023PubMedID: 36125530Scopus ID: 2-s2.0-85138146668OAI: oai:DiVA.org:oru-101429DiVA, id: diva2:1698437
Funder
Swedish Research CouncilSwedish Cancer SocietySwedish Society of MedicineForte, Swedish Research Council for Health, Working Life and WelfareNovo NordiskKarolinska Institute
Note

Funding agencies:

Bengt Ihre Research Foundation 

Bengt Ihre Research Fellowship

Young Scholar Award from the Strategic Research Area Epidemiology Program at Karolinska Institutet

Independent Research Fund Denmark 

Danish Cancer Association

Regional Agreement on Medical Training and Clinical Research between Stockholm County Council

Available from: 2022-09-23 Created: 2022-09-23 Last updated: 2025-02-11Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Ludvigsson, Jonas F.Halfvarson, Jonas

Search in DiVA

By author/editor
Ludvigsson, Jonas F.Halfvarson, Jonas
By organisation
School of Medical SciencesÖrebro University Hospital
In the same journal
Journal of Pediatric Gastroenterology and Nutrition - JPGN
Gastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 28 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf