Colorectal Cancer in Childhood-onset Inflammatory Bowel Disease: A Scandinavian Register-based Cohort Study, 1969-2017Show others and affiliations
2022 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 75, no 4, p. 480-484Article in journal (Refereed) Published
Abstract [en]
Through linkage of data from Danish and Swedish national registers we identified 6937 patients with childhood (<18 years)-onset Crohn disease (CD), 8514 patients with childhood-onset ulcerative colitis (UC) and up to 10 times as many matched (sex, age, residence) reference individuals 1969-2017. During follow-up to a median age of 27 (interquartile range = 21-39) years, 25 (0.36%) CD patients were diagnosed with colorectal cancer (CRC) versus 43 (0.06%) reference individuals, and 113 (1.33%) UC patients versus 45 (0.05%) reference individuals. The hazard ratio (HR) for CRC was 6.46 (95% CI = 3.95-10.6) in CD and 32.5 (95% CI = 23.0-45.9) in UC and increased with decreasing age at diagnosis. The HR for CRC was increased for all phenotypes, but with higher estimates for colonic CD [17.9 (95% CI = 7.43-43.3)] and UC with extensive/pancolitis [36.3 (95% CI = 22.8-57.8)]. The relative risk of CRC was increased for all phenotypes of childhood-onset inflammatory bowel disease. Age at onset may be considered an additional risk factor when implementing surveillance programs.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2022. Vol. 75, no 4, p. 480-484
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-101429DOI: 10.1097/MPG.0000000000003574ISI: 000855495300023PubMedID: 36125530Scopus ID: 2-s2.0-85138146668OAI: oai:DiVA.org:oru-101429DiVA, id: diva2:1698437
Funder
Swedish Research CouncilSwedish Cancer SocietySwedish Society of MedicineForte, Swedish Research Council for Health, Working Life and WelfareNovo NordiskKarolinska Institute
Note
Funding agencies:
Bengt Ihre Research Foundation
Bengt Ihre Research Fellowship
Young Scholar Award from the Strategic Research Area Epidemiology Program at Karolinska Institutet
Independent Research Fund Denmark
Danish Cancer Association
Regional Agreement on Medical Training and Clinical Research between Stockholm County Council
2022-09-232022-09-232025-02-11Bibliographically approved