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Outcome After Surgery for Acute Type A Aortic Dissection With or Without Primary Tear Resection
Tampere University Heart Hospital, Tampere University, Tampere, Finland; Tampere University, Tampere, Finland.
Karolinska University Hospital, Stockholm, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Division of Cardiac Surgery, Yale School of Medicine, New Haven, Connecticut.
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2022 (English)In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 114, no 2, p. 492-501Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The outcome in patients after surgery for acute type A aortic dissection without replacement of the part of the aorta containing the primary tear is undefined.

METHODS: Data of 1122 patients who underwent surgery for acute type A aortic dissection in 8 Nordic centers from January 2005 to December 2014 were retrospectively analyzed. The patients with primary tear location unfound, un-known, not confirmed, or not recorded (n = 243, 21.7%) were excluded from the analysis. The patients were divided into 2 groups according to whether the aortic reconstruction encompassed the portion of the primary tear (tear resected [TR] group, n = 730) or not (tear not resected [TNR] group, n = 149). The restricted mean survival time ratios adjusted for patient characteristics and surgical details between the groups were calculated for all-cause mortality and aortic reoperation-free survival. The median follow-up time was 2.57 (interquartile range, 0.53-5.30) years.

RESULTS: For the majority of the patients in the TR group, the primary tear was located in the ascending aorta (83.6%). The reconstruction encompassed both the aortic root and the aortic arch in 7.4% in the TR group as compared with 0.7% in the TNR patients (P < .001). There were no significant differences in all-cause mortality (adjusted restricted mean survival time ratio, 1.01; 95% confidence interval, 0.92-1.12; P = .799) or reoperation-free survival (adjusted restricted mean survival time ratio, 0.98; 95% confidence interval, 0.95-1.02; P = .436) between the TR and TNR groups.

CONCLUSIONS: Primary tear resection alone does not determine the midterm outcome after surgery for acute type A aortic dissection. (Ann Thorac Surg 2022;114:492-501) (c) 2022 by The Society of Thoracic Surgeons.

Place, publisher, year, edition, pages
Elsevier, 2022. Vol. 114, no 2, p. 492-501
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Cardiology and Cardiovascular Disease Surgery
Identifiers
URN: urn:nbn:se:oru:diva-101963DOI: 10.1016/j.athoracsur.2021.09.067ISI: 000865422000023PubMedID: 34774491Scopus ID: 2-s2.0-85123620613OAI: oai:DiVA.org:oru-101963DiVA, id: diva2:1706644
Note

Funding agencies:

Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital

Finnish Cultural Foundation from Pirkanmaa Regional Fund

The Mats Kleberg Foundation, Stockholm, Sweden

University of Iceland Research Fund

Lanspitali Research Fund

Available from: 2022-10-27 Created: 2022-10-27 Last updated: 2025-02-10Bibliographically approved

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Wickbom, Anders

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