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Associations Between Attention Deficit Hyperactivity Disorder Symptom Dimensions and Disordered Eating Symptoms in Adolescence: A Population-Based Twin Study
National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Psychology, University of South Carolina, Columbia, SC, USA.
Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, India.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2023 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 53, no 2, p. 143-153Article in journal (Refereed) Published
Abstract [en]

Although bivariate associations between attention-deficit/hyperactivity disorder (ADHD) and eating disorders in adolescent girls and boys have been previously identified, the mechanistic link underlying the symptom-level associations remains unclear. We evaluated shared genetic and environmental influences on ADHD symptoms and disordered eating in 819 female and 756 male twins from the Swedish TCHAD cohort using bivariate models. Common additive genetic and unique environmental effects accounted for majority of ADHD and disordered eating associations in a differential manner. For girls, the strongest genetic correlation was observed for cognitive/inattention problems-bulimia (0.54), with genetic factors accounting for 67% of the phenotypic correlation. For boys, the strongest genetic correlations were observed for conduct problems-bulimia and hyperactivity-bulimia (~ 0.54), accounting for 83% and 95% of the phenotypic correlation, respectively. As per our findings, the risk of comorbidity and shared genetics highlights the need for preventative measures and specialized treatment for ADHD and disordered eating in both sexes.

Place, publisher, year, edition, pages
Springer, 2023. Vol. 53, no 2, p. 143-153
Keywords [en]
Attention-deficit/hyperactivity disorder, Disordered eating, Genetics, Population cohort, Sex differences, Symptom-level associations, Twin study
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-102655DOI: 10.1007/s10519-022-10128-5ISI: 000896029200001PubMedID: 36484893Scopus ID: 2-s2.0-85143604736OAI: oai:DiVA.org:oru-102655DiVA, id: diva2:1718314
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2004-0383Swedish Research Council, 2004-1415 538-2013-8864
Note

Funding agency:

United States Department of Health & Human Services

National Institutes of Health (NIH) - USA

NIH National Institute of Mental Health (NIMH) T32MH076694 K01MH109782  R01MH120170  

Brain and Behavior Research Foundation NARSAD Young Investigator Award 28799

NIH National Institute of General Medical Sciences (NIGMS) T32GM081740 

Lundbeckfonden R276-2018-4581  

United States Department of Health & Human Services

National Institutes of Health (NIH) - USA

NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K23DK120517  

NIH National Institute of Mental Health (NIMH) K01MH106675

Available from: 2022-12-12 Created: 2022-12-12 Last updated: 2024-04-08Bibliographically approved

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Larsson, Henrik

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