Translational implications of bradyarrhythmia in hibernating brown bearsShow others and affiliations
2023 (English)In: Physiological Reports, E-ISSN 2051-817X, Vol. 11, no 1, article id e15550Article in journal (Refereed) Published
Abstract [en]
The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.
Place, publisher, year, edition, pages
John Wiley & Sons, 2023. Vol. 11, no 1, article id e15550
Keywords [en]
Ursus arctos, bradyarrhythmia, brown bear, hibernation, sinus arrest, sinus node disease, sinus pause, syncope, translational model
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-103157DOI: 10.14814/phy2.15550ISI: 000906613600001PubMedID: 36597216Scopus ID: 2-s2.0-85145430728OAI: oai:DiVA.org:oru-103157DiVA, id: diva2:1729120
2023-01-192023-01-192024-01-16Bibliographically approved