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Shared Genetic Factors Contributing to the Overlap between Attention-Deficit/Hyperactivity Disorder Symptoms and Overweight/Obesity in Swedish Adolescent Girls and Boys
Division of Women's Mental Health, McLean Hospital, Belmont, Massachusetts, USA; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
CAUSALab, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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2022 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 25, no 6, p. 226-233Article in journal (Refereed) Published
Abstract [en]

Attention-deficit/hyperactivity disorder (ADHD) and obesity are positively associated, with increasing evidence that they share genetic risk factors. Our aim was to examine whether these findings apply to both types of ADHD symptoms for female and male adolescents. We used data from 791 girl and 735 boy twins ages 16-17 years to examine sex-specific phenotypic correlations between the presence of ADHD symptoms and overweight/obese status. For correlations exceeding .20, we then fit bivariate twin models to estimate the genetic and environmental correlations between the presence of ADHD symptoms and overweight/obese status. ADHD symptoms and height/weight were parent- and self-reported, respectively. Phenotypic correlations were .30 (girls) and .08 (boys) for inattention and overweight/obese status and .23 (girls) and .14 (boys) for hyperactivity/impulsivity and overweight/obese status. In girls, both types of ADHD symptoms and overweight/obese status were highly heritable, with unique environmental effects comprising the remaining variance. Furthermore, shared genetic effects explained most of the phenotypic correlations in girls. Results suggest that the positive association of both types of ADHD symptoms with obesity may be stronger in girls than boys. Further, in girls, these associations may stem primarily from shared genetic factors.

Place, publisher, year, edition, pages
Cambridge University Press, 2022. Vol. 25, no 6, p. 226-233
Keywords [en]
Obesity, attention-deficit/hyperactivity disorder, genetics, hyperactivity/impulsivity, inattention
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-103167DOI: 10.1017/thg.2022.35ISI: 000912714200001PubMedID: 36633106Scopus ID: 2-s2.0-85147834188OAI: oai:DiVA.org:oru-103167DiVA, id: diva2:1729892
Funder
Swedish Research Council, 2018-02599 FO2021-0115European Commission, 965381
Note

Funding agencies:

United States Department of Health & Human Services

National Institutes of Health (NIH) - USA

NIH National Institute of Mental Health (NIMH) T32-MH076694 R01-MH119084 R01-MH118278 K23-DK120517 K01-AA025113 538-2013-8864  

NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K01-MH109782  M

NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R01-MH120170  

Brain and Behavior Research Foundation Distinguished Investigator Grant

Martini Family Foundation

McLean Hospital Women's Mental Health Innovation Fund

Lundbeckfonden R276-2018-4581

Available from: 2023-01-23 Created: 2023-01-23 Last updated: 2023-12-08Bibliographically approved

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