Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel DiseaseShow others and affiliations
2023 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 17, no 6, p. 919-932Article in journal (Refereed) Published
Abstract [en]
Biomarkers to guide clinical decision-making at diagnosis of inflammatory bowel disease (IBD) are urgently needed. We investigated a composite serum N-glycomic biomarker to predict future disease course in a discovery cohort of 244 newly diagnosed IBD patients. Forty-seven individual glycan peaks were analysed using ultra-high performance liquid chromatography identifying 105 glycoforms from which 24 derived glycan traits were calculated. Multivariable logistic regression was performed to determine associations of derived glycan traits with disease. Cox proportional hazard models were used to predict treatment escalation from first-line treatment to biologics or surgery (hazard ratio (HR) 25.9, p=1.1×10-12; 95% confidence interval (CI), 8.52-78.78). Application to an independent replication cohort of 54 IBD patients yielded a HR of 5.1 (p=1.1×10-5; 95% CI, 2.54-10.1). These data demonstrate the prognostic capacity of serum N-glycan biomarkers and represent a step towards personalized medicine in IBD.
Place, publisher, year, edition, pages
Oxford University Press, 2023. Vol. 17, no 6, p. 919-932
Keywords [en]
Biomarker, Crohn's disease, N-Glycans, Personalised treatment, Prognosis, Ulcerative colitis
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-103595DOI: 10.1093/ecco-jcc/jjad012ISI: 000944979400001PubMedID: 36694402Scopus ID: 2-s2.0-85159095357OAI: oai:DiVA.org:oru-103595DiVA, id: diva2:1731146
2023-01-262023-01-262023-12-08Bibliographically approved