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Visual Function and Fundus Morphology in Relation to Growth and Cardiovascular Status in 10-Year-Old Moderate-to-Late Preterm Children
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska University Hospital, Gothenburg, Sweden.
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2018 (English)In: American Journal of Ophthalmology, ISSN 0002-9394, E-ISSN 1879-1891, Vol. 195, p. 121-130Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To study visual function and ocular fundus morphology in relation to growth, metabolic status, and blood pressure in moderate-to-late preterm (MLP) children at 10 years of age.

DESIGN: Prospective cohort study.

METHODS: In this population-based observational study, nonsyndromic MLP children born in Gothenburg, Sweden, were examined neonatally in the years 2002-2003 concerning length, weight, head circumference, and insulin-like growth factor I (IGF-I). At 10 years of age, 33 children (10 girls) were examined regarding previously mentioned variables, and regarding visual acuity, refraction, fundus morphology, IGF binding protein 3, leptin, adiponectin, and blood pressure. An age- and sex-matched control group consisted of 28 children (9 girls).

RESULTS: Myopia was more commonly found in MLP children than in controls (P = .004, 95% CI 1.8 to 49.8). The MLP group had smaller optic disc area (P = .01, 95% CI -0.5 to -0.1), smaller rim area (P = .001, 95% CI -0.5 to -0.2), fewer branching points (P = .0001, 95% CI -5.7 to -2.1), and higher index of tortuosity of arteries (P = .03, 95% CI 0.002 to 0.03) and veins (P = .02, 95% CI 0.003 to 0.02). Refraction correlated with IGF-I (P = .0005, rs = 0.60 in right eye, and P = .002, rs = 0.55 in left eye) at 10 years of age. Tortuosity of arteries at assessment correlated with neonatal IGF-I levels (P = .03, rs = -0.39). Tortuosity of veins correlated with a leptin/adiponectin ratio at assessment (P = .04, rs = 0.37).

CONCLUSION: The findings suggest that being born MLP is associated with myopia, smaller optic disc and rim areas, and abnormal retinal vascularization. Furthermore, metabolic status and growth factors seem to have an impact on ocular development.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 195, p. 121-130
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:oru:diva-103794DOI: 10.1016/j.ajo.2018.07.037ISI: 000450020300017PubMedID: 30081018Scopus ID: 2-s2.0-85052872527OAI: oai:DiVA.org:oru-103794DiVA, id: diva2:1732037
Funder
Swedish Society of MedicineSwedish Research Council
Note

Funding Agencies:

GOTHENBURG MEDICAL SOCIETY (GOTHENBURG, SWEDEN)

De Blindas Vänner (Stockholm, Sweden)

Research and Education of Doctors (Gothenburg, Sweden)

Available from: 2023-01-30 Created: 2023-01-30 Last updated: 2024-01-02Bibliographically approved

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Andersson Grönlund, Marita

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