Cord serum metabolic signatures of future progression to immune-mediated diseasesShow others and affiliations
2023 (English)In: iScience, E-ISSN 2589-0042 , Vol. 26, no 3, article id 106268Article in journal (Refereed) Published
Abstract [en]
Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases. Here we investigated metabolic profiles in cord serum in a general population cohort (All Babies In Southeast Sweden; ABIS), comprising infants who progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 12), celiac disease (n = 28), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), and hypothyroidism (n = 6); and matched controls (n = 270). We observed elevated levels of multiple triacylglycerols (TGs) an alteration in several gut microbiota related metabolites in the autoimmune groups. The most distinct differences were observed in those infants who later developed HT. The specific similarities observed in metabolic profiles across autoimmune diseases suggest that they share specific common metabolic phenotypes at birth that contrast with those of healthy controls.
Place, publisher, year, edition, pages
Cell Press , 2023. Vol. 26, no 3, article id 106268
Keywords [en]
Health sciences, Human metabolism, Immunology, Lipidomics, Metabolomics
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-104968DOI: 10.1016/j.isci.2023.106268ISI: 000995062700001PubMedID: 36915680Scopus ID: 2-s2.0-85150925263OAI: oai:DiVA.org:oru-104968DiVA, id: diva2:1743487
Funder
Swedish Research Council, 2020-03674 K2005-72 x -11242-11A K2008-69 x -20826-01-4Swedish Research Council Formas, 2019-00869Swedish Child Diabetes FoundationForte, Swedish Research Council for Health, Working Life and Welfare, FAS2004-1775Medical Research Council of Southeast Sweden (FORSS)Swedish Child Diabetes FoundationWallenberg Foundations, K 98-99D-12813-01ARegion ÖstergötlandLinköpings universitet
Note
Funding agency:
Östgöta Brandstodsbolag
2023-03-152023-03-152025-02-11Bibliographically approved