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A 12-year experience of endovascular repair for ruptured abdominal aortic aneurysms in all patients
Örebro University, School of Medical Sciences. Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-0805-4823
Department of Cardiothoracic and Vascular Surgery, Linköping University Hospital, Linköping, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Cardiothoracic and Vascular Surgery.ORCID iD: 0000-0001-7667-5600
Örebro University, School of Medical Sciences. Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-8461-5074
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2023 (English)In: Journal of Vascular Surgery, ISSN 0741-5214, E-ISSN 1097-6809, Vol. 77, no 3, p. 741-749Article in journal (Refereed) Published
Abstract [en]

Objective: Endovascular aneurysm repair (EVAR) has been increasingly performed for ruptured abdominal aortic aneurysms (rAAAs). However, multiple randomized trials have failed to demonstrate a survival benefit compared with open aortic surgery. During a 12-year period, 100% of patients without a history of aneurysm surgery had undergone EVAR for a rAAA at orebro University Hospital, with no emergent open aortic surgery performed. In the present study, we evaluated the mortality and technical success during this "EVAR-only" period.

Methods: A single-center, retrospective observational study was conducted. We identified all patients who had presented to Orebro University Hospital with a rAAA between October 2009 and September 2021. Patients with isolated iliac artery, thoracic, and thoracoabdominal aortic ruptures were not included. Patients who had received previous aortic interventions (open or endovascular) and patients who had received palliative treatment instead of surgical intervention were also excluded. The patient characteristics, perioperative and postoperative data, and mortality rate were investigated.

Results: EVAR had been performed in 100 patients. Preoperative hemodynamic instability had been present in 54 patients (54%), and 18 (18%) had undergone aortic balloon occlusion. The aneurysm location was infrarenal in 89 patients (89%). Bifurcated stent grafts had been used in 97 patients (97%), and adjunct endovascular techniques had been used for 27 patients (27%). Of 98 patients, EVAR had been performed with the patient under local anesthesia for 62 patients (63%). Peri-and postoperative complications at 30 days had occurred in 20 of 100 patients (20%) and 22 of 79 patients (28%), respectively. The overall mortality at 30 days was 27% (27 of 100 patients), and the mortality for those with an isolated infrarenal rAAA was 24% (21 of 89 patients). The overall mortality at 1 year was 39% (39 of 100 patients) and for those with an isolated infrarenal rAAA was 37% (33 of 89 patients). The presence of preoperative hemodynamic instability and the use of ABO were statistically significantly and independently associated with increased 30-day mortality on multivariate logistic regression analysis.

Conclusions: All 100 patients who had undergone surgery for a rAAA had been treated using EVAR and endovascular adjuncts, with a relatively low mortality rate, thus continuing the "EVAR-only" approach. A low proportion of rAAA patients were considered surgically unsuitable. These findings support the applicability of EVAR for the treatment of all rAAAs at suitable centers.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 77, no 3, p. 741-749
Keywords [en]
Aortic aneurysm, Aortic rupture, Endovascular aortic repair, Endovascular procedures
National Category
Surgery Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-105412DOI: 10.1016/j.jvs.2022.10.032ISI: 000952530400001PubMedID: 37276170Scopus ID: 2-s2.0-85143604283OAI: oai:DiVA.org:oru-105412DiVA, id: diva2:1750028
Available from: 2023-04-12 Created: 2023-04-12 Last updated: 2024-05-14Bibliographically approved
In thesis
1. EndoVascular resuscitation and Trauma Management in hemodynamic instability
Open this publication in new window or tab >>EndoVascular resuscitation and Trauma Management in hemodynamic instability
2024 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Massive bleeding is a significant health care challenge, particularly in the case of non-compressible torso hemorrhage, with both traumatic and non-traumatic causes. The management of bleeding in the torso poses unique challenges, both anatomically and physiologically. The concept of Endo-Vascular resuscitation and Trauma Management (EVTM) has evolved alongside endovascular surgery over the past two decades. It combines modern endovascular surgical techniques with traditional open surgical management to provide early evaluation, resuscitation, and definitive treatment of both traumatic and non-traumatic bleeding patients. The purpose of this thesis was to investigate the feasibility, outcomes and practice patterns of EVTM in patients with hemodynamic instability.

Study I was a retrospective cohort study assessing the consecutive use of Endovascular Aortic Repair (EVAR) for all 100 patients with ruptured ab-dominal aortic aneurysms (rAAA). Mortality at 30 days was 27% with a turndown rate of 3.5%.

Study II was a retrospective cohort study examining the use of resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with impending traumatic cardiac arrest showing that vascular access is feasible and REBOA increases systolic blood pressure (SBP).

Study III & IV were animal experimental studies evaluating the use of RE-BOA for hemodynamic instability due to intrathoracic bleeding or acute cardiac tamponade. They showed that REBOA, using different occlusion techniques, maintains permissive hypotension, carotid blood flow and prolongs survival.

Study V was a retrospective cohort study comparing outcomes and practice patterns for patients with grade 3 or 4 blunt thoracic aortic injury (BTAI) treated with TEVAR. Hemodynamically unstable patients have increased risk of complications, prolonged length of hospital stay and increased levels of in-hospital mortality.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2024. p. 95
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 293
Keywords
Endovascular, hemorrhage, hemodynamic instability, REBOA, endografts, rAAA, BTAI, resuscitation, trauma, intrathoracic bleeding, acute cardiac tamponade
National Category
Surgery
Identifiers
urn:nbn:se:oru:diva-112753 (URN)9789175295596 (ISBN)9789175295602 (ISBN)
Public defence
2024-06-07, Örebro universitet, Campus USÖ, X2502, Tidefeltsalen, Södra Grev Rosengatan 32, Örebro, 09:00 (Swedish)
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Supervisors
Available from: 2024-04-02 Created: 2024-04-02 Last updated: 2024-05-28Bibliographically approved

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McGreevy, David T.Gidlund, Khatereh DjavaniNilsson, Kristofer F.Hörer, Tal M.

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