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Anxiety, mood, and substance use disorders in adult men and women with and without Attention-Deficit/Hyperactivity Disorder: a substantive and methodological overview
University Medical Center Groningen, Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University of Groningen, the Netherlands.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Child- and adolescent psychiatric outpatient unit, Hospital Betanien, Bergen, Norway; Department of Biomedicine, University of Bergen, Norway.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2023 (English)In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 151, article id 105209Article, review/survey (Refereed) Published
Abstract [en]

Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n> 10,000; surveys, claims data, population registries) to identify (a) overall, (b) sex- and (c) age-specific patterns of comorbidity of anxiety disorders (ADs), major depressive disorder (MDD), bipolar disorder (BD) and substance use disorders (SUDs) in adults with ADHD relative to adults without ADHD; and (2) describes methodological challenges relating to establishing comorbidity in ADHD in adults as well as priorities for future research. Meta-analyses (ADHD: n=550,748; no ADHD n=14,546,814) yielded pooled odds ratios of 5.0(CI:3.29-7.46) for AD, 4.5(CI:2.44-8.34) for MDD, 8.7(CI:5.47-13.89) for BD and 4.6(CI:2.72-7.80) for SUDs, indicating strong differences in adults with compared to adults without ADHD. Moderation by sex was not found: high comorbidity held for both men and women with sex-specific patterns as in the general population: higher prevalences of ADs, MDD and BD in women and a higher prevalence of SUDs in men. Insufficient data on different phases of the adult lifespan prevented conclusions on developmental changes in comorbidity. We discuss methodological challenges, knowledge gaps, and future research priorities.

Place, publisher, year, edition, pages
Pergamon Press, 2023. Vol. 151, article id 105209
Keywords [en]
Adults, Attention-Deficit/Hyperactivity Disorder, Comorbidity, Lifespan Life course, Sex differences, Anxiety Disorders, Major Depressive Disorder, Bipolar Disorder, Substance Use Disorders
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-105866DOI: 10.1016/j.neubiorev.2023.105209ISI: 001004474400001PubMedID: 37149075Scopus ID: 2-s2.0-8515921650OAI: oai:DiVA.org:oru-105866DiVA, id: diva2:1755305
Funder
EU, Horizon 2020, 667302 728018 965381
Note

Funding agencies:

Spanish Ministerio de Ciencia, Innovacion y Universidades' PID2021-1277760B-I100

Generalitat de Catalunya/AGAUR' 2021-SGR-01093

ICREA Academia 2021

Fundacio La Marato de TV3' 202218-31

ECNP network of ADHD across the lifespan

United States Department of Health & Human Services

National Institutes of Health (NIH) - USA

NIH National Institute of Mental Health (NIMH) U01MH109536-01 U01AR076092-01A1 R0MH116037 5R01AG06495502

Available from: 2023-05-08 Created: 2023-05-08 Last updated: 2023-08-02Bibliographically approved

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