Epidemiological overview of major depressive disorder in Scandinavia using nationwide registersDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Department of Science and Environment, Roskilde University, Denmark.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
College of Pharmacy, University of Manitoba, Canada.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Lundbeck Foundation GeoGenetics Centre, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; NORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Norway.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden; K.G. Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark.
Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway; Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, NC, USA; Centre of Research and Education in Forensic Psychiatry, Oslo University Hospital, Oslo, Norway.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
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2023 (English)In: The Lancet Regional Health: Europe, E-ISSN 2666-7762, Vol. 29, article id 100621Article in journal (Refereed) Published
Abstract [en]
BACKGROUND: Major depressive disorder (MDD) is a common psychiatric disorder associated with a high disease burden. This study gives a comprehensive overview of the prevalence, outcomes, treatment, and genetic epidemiology of MDD within and across the Scandinavian countries.
METHODS: This study has aimed to assess and compare across Norway, Denmark, and Sweden 1) the prevalence and trajectories of MDD and comorbidity, 2) outcomes and treatment, and 3) heritability (Denmark and Sweden only). The analyses leveraged data on 272,944 MDD cases (and 6.2 million non-cases) from Norway, Sweden, and Denmark in specialist care in national longitudinal health registers covering 1975-2013. Relying on harmonized public data global comparisons of socioeconomic and health metrics were performed to assess to what extent findings are generalizable.
FINDINGS: MDD ranked among the most prevalent psychiatric disorders. For many cases, the disorder trajectory was severe, with varying proportions experiencing recurrence, developing comorbid disorders, requiring inpatient treatment, or dying of suicide. Important country differences in specialist care prevalence and treatment were observed. Heritability estimates were moderate (35-48%). In terms of socioeconomic and health indices, the Scandinavian nations were comparable to one another and grouped with other Western nations.
INTERPRETATION: The Scandinavian countries were similar with regards to MDD epidemiological measures, but we show that differences in health care organization need to be taken into consideration when comparing countries. This study demonstrates the utility of using comprehensive population-wide registry data, outlining possibilities for other applications. The findings will be of use to policy makers for developing better prevention and intervention strategies.
Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 29, article id 100621
Keywords [en]
Electronic health records, Epidemiology, Heritability, Major depressive disorder, National patient register
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-106362DOI: 10.1016/j.lanepe.2023.100621ISI: 001029126800001PubMedID: 37265784Scopus ID: 2-s2.0-85157978635OAI: oai:DiVA.org:oru-106362DiVA, id: diva2:1773103
Funder
Swedish Research Council, D0886501EU, Horizon 2020, 847776 964874EU, European Research Council, 101042183
Note
Funding agency:
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA
NIH National Institute of Mental Health (NIMH) R01 MH123724
2023-06-222023-06-222023-09-05Bibliographically approved