To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Trends in the incidence, prevalence and sales volume of menopausal hormone therapy in Sweden from 2000 to 2021
Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden; Department of Obstetrics and Gynaecology, Kalmar, County Hospital, 391 85 Kalmar, Sweden.
Örebro University, School of Medical Sciences. Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden; Department of Obstetrics and Gynecology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-0071-4383
Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden; Department of Obstetrics and Gynaecology, Linköping University Hospital, 581 85 Linköping, Sweden.
Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.
Show others and affiliations
2023 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 175, article id 107787Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To describe the trends in the prevalence of use menopausal hormone therapy (MHT) in Sweden over the period 2000-2021 and to analyse the impact of different lengths of run-in on the calculated incident use. STUDY DESIGN: Individual-level data on MHT dispensations for 2.5 million women aged 45-69 years for the period 2006-2021 were analysed. Aggregated sales volumes in defined daily dose (DDD) were available for the whole study period (2000-2021).

MAIN OUTCOME MEASURES: One-year prevalence and one-year incidence (18-month run-in) per 1000 women and DDD per 1000 women per day of MHT were the main outcome measures. The predictive values for incidence representing first-ever use of MHT were calculated for different run-in periods, which is a defined period without dispensations.

RESULTS: Both the DDD, from 2000, and the prevalence, from 2006, decreased by over 80 % in women aged 50-54 years, until 2010, when the use of MHT stabilised. The predictive value for incident users to be first-ever users was 88 % in women aged 50-54 years, with a run-in of 18 months, in 2021. The incidence was stable between 2007 and 2016. From 2017 the incidence increased, being most pronounced for women close to menopause.

CONCLUSIONS: MHT use decreased significantly after the turn of the century, but has increased since 2017. A run-in period of 18 months was found suitable and reliable for defining incident users of MHT in the age intervals closest to menopause. Incidence seems to be a more sensitive measure than prevalence or DDD for the early detection of changes in trends in prescriptions of MHT.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 175, article id 107787
Keywords [en]
Climacteric, Hormone replacement therapy, Incidence, Menopausal hormone therapy, Pharmacoepidemiology, Run-in period
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-106594DOI: 10.1016/j.maturitas.2023.107787ISI: 001030486100001PubMedID: 37354643Scopus ID: 2-s2.0-85162266765OAI: oai:DiVA.org:oru-106594DiVA, id: diva2:1775830
Note

Funding agencies:

The Medical Research Council of Southeast Sweden FORSS-646401 FORSS-746391

NEPI Foundation - the Swedish Network for Pharmacoepidemiology, Stockholm, Sweden

Available from: 2023-06-27 Created: 2023-06-27 Last updated: 2024-01-02Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Brynhildsen, Jan

Search in DiVA

By author/editor
Brynhildsen, Jan
By organisation
School of Medical Sciences
In the same journal
Maturitas
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 32 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf