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Changes in prevalence of non-optimal neurological condition between 6.5 and 12 years in children born extremely preterm
Paediatric Department, Örebro University Hospital, Örebro, Sweden.
Neonatal Research Unit, Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden; Sachs’ Children and Youth Hospital, Stockholm, Sweden.
Sachs’ Children and Youth Hospital, Stockholm, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Science and Education Södersjukhuset, Stockholm, Sweden.
Neonatal Research Unit, Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden; Department of Bioclinical Sciences, Linköping University, Sweden.
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2023 (English)In: European journal of paediatric neurology, ISSN 1090-3798, E-ISSN 1532-2130, Vol. 45, p. 14-18Article in journal (Refereed) Published
Abstract [en]

Aim: To assess prevalence of non-optimal neurological condition and associations with motor function in children born extremely preterm (EPT) up to early adolescence, and to examine potential changes in neurological con-dition between 6.5 and 12 years.

Method: A prospective cohort of one hundred six children (EPT n = 62, term n = 44) was assessed at 6.5 and 12 years. Four domains derived from the Touwen Neurological Examination (coordination and balance, posture and muscle tone, reflexes, and nerve function of the eyes and face) were used to assess the presence of a non-optimal neurological condition (defined as the presence of any abnormal domain). The Movement Assessment Battery for Children 2nd ed. was used to evaluate motor function.

Results: Twenty-seven children born EPT (44%) were assessed as having a non-optimal neurological condition compared with 4 (9%) in the control group (p=<0.001) at 12 years. Between age 6.5 and 12 years the number of children born EPT with a non-optimal neurological condition decreased from 37 to 27 (p = 0.007). At 12 years these children also had significantly lower MABC-2 total test scores, compared to those with normal neurology: median (range) 57 (32-79) versus 75 (43-99), respectively (p=<0.001). The same was shown for subscale scores; manual dexterity (p=<0.001), aiming/catching (p = 0.004), and balance (p = 0.004).

Conclusion: The prevalence of a non-optimal neurological condition reduced with increasing age. However, still, at 12 years, these neurological impairments remained significantly more common in the EPT group than in their term-born peers and was shown to be related to a reduced motor function.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 45, p. 14-18
Keywords [en]
Extremely preterm, Neurodevelopment, Neurological dysfunction, Prevalence, Motor function, Minor neurological dysfunction
National Category
Pediatrics Neurology
Identifiers
URN: urn:nbn:se:oru:diva-107290DOI: 10.1016/j.ejpn.2023.05.007ISI: 001013289500001PubMedID: 37244031Scopus ID: 2-s2.0-85159848730OAI: oai:DiVA.org:oru-107290DiVA, id: diva2:1785484
Funder
Region StockholmKarolinska InstituteSwedish Society of MedicineThe Swedish Brain FoundationSällskapet BarnavårdSamariten foundation for paediatric researchStiftelsen drottning Silvias jubileumsfondSven Jerring Foundation
Note

Funding agencies:

Swedish Medical Research Council (SMRC)

Swedish Order of Freemasons in Stockholm

Cocozza foundation 

Philipson Foundation

Promobilia Foundation Sweden 

Frimuraren

Available from: 2023-08-02 Created: 2023-08-02 Last updated: 2023-08-17Bibliographically approved

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Nosko, Daniela

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