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Symptoms of multiple sclerosis in women in relation to sex steroid exposure
Division of Obstetrics & Gynaecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Obstetrics & Gynaecology, County Hospital Sundsvall, Sweden.
Division of Obstetrics & Gynaecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Division of Obstetrics & Gynaecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Division of Obstetrics & Gynaecology, Department of Molecular and Clinical Medicine, Faculty of Division of Neurology, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
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2006 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 54, no 2, p. 149-153Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate if women with multiple sclerosis (MS) experience changes in MS symptoms related to pregnancy, the postpartum period, menopause or use of oral contraception (OC) or postmenopausal hormone therapy (HT).

Methods: Women with diagnosed MS were recruited from registers of all MS patients known in two counties of Sweden, respectively. Ninety-four women were recruited in Linkoping and 52 in Sundsvall. The women answered a questionnaire with categorized alternatives regarding their MS symptoms related to menstruation, pregnancy, delivery, menopause and use of OC 41 or FIT.

Results: Forty percent of the women reported worsening of MS symptoms related to menopause, whereas 56% reported no change of symptoms and 5% reported decreased symptoms. More than a fourth of the women reported decreased symptoms during pregnancy, 64% reported unchanged symptoms and 10% reported increased symptoms. Every third woman reported increased symptoms after delivery, 59% reported no change and 5% reported decreased symptoms. Few women reported changes in MS symptoms in relation to use of HT or OC.

Conclusion: The presented data indicate a relationship between high-oestrogen states and ameliorated symptoms whereas low-oestrogen states seem to relate to a worsening of the disease. A majority of women, however, reported no changes in MS symptoms in relation to the different oestrogen states.

Place, publisher, year, edition, pages
Elsevier, 2006. Vol. 54, no 2, p. 149-153
Keywords [en]
Multiple sclerosis oestrogen, immunology, menopause, hormone therapy
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-107971DOI: 10.1016/j.maturitas.2005.10.003ISI: 000237948200007PubMedID: 16293376Scopus ID: 2-s2.0-33748075167OAI: oai:DiVA.org:oru-107971DiVA, id: diva2:1793051
Available from: 2023-08-31 Created: 2023-08-31 Last updated: 2024-01-02Bibliographically approved

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