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B Cell Tolerance and Targeted Therapies in SLE
Örebro University, School of Medical Sciences. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 17177 Stockholm, Sweden; Department of Gastroenterology, Dermatology and Rheumatology, Karolinska University Hospital, 17176 Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-4875-5395
Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
2023 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 12, no 19, article id 6268Article, review/survey (Refereed) Published
Abstract [en]

Systemic Lupus Erythematosus (SLE) is a chronic systemic autoimmune disease of high clinical and molecular heterogeneity, and a relapsing-remitting pattern. The disease is currently without cure and more prevalent in women. B cell tolerance and production of autoantibodies are critical mechanisms that drive SLE pathophysiology. However, how the balance of the immune system is broken and how the innate and adaptive immune systems are interacting during lupus-specific autoimmune responses are still largely unknown. Here, we review the latest knowledge on B cell development, maturation, and central versus peripheral tolerance in connection to SLE and treatment options. We also discuss the regulation of B cells by conventional T cells, granulocytes, and unconventional T cells, and how effector B cells exert their functions in SLE. We also discuss mechanisms of action of B cell-targeted therapies, as well as possible future directions based on current knowledge of B cell biology.

Place, publisher, year, edition, pages
MDPI, 2023. Vol. 12, no 19, article id 6268
Keywords [en]
B cell tolerance, NKT cells, SLE, lupus, neutrophils
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:oru:diva-108982DOI: 10.3390/jcm12196268ISI: 001083055400001PubMedID: 37834911Scopus ID: 2-s2.0-85173902800OAI: oai:DiVA.org:oru-108982DiVA, id: diva2:1805074
Funder
Swedish Rheumatism Association, R-969696King Gustaf V Jubilee Fund, FAI-2020-0741Swedish Society of Medicine, SLS-974449Nyckelfonden, OLL-974804Region Stockholm, FoUI-955483Swedish Research CouncilWenner-Gren FoundationsKarolinska Institute
Note

This research was funded by: the Swedish Rheumatism Association, grant number R-969696; King Gustaf V's 80-year Foundation, grant number FAI-2020-0741; Swedish Society of Medicine, grant number SLS-974449; Nyckelfonden, grant number OLL-974804; Professor Nanna Svartz Foundation, grant number 2021-00436; Ulla and Roland Gustafsson Foundation, grant number 2021-26; Region Stockholm, grant number FoUI-955483; Swedish Research Council; Wennergren Foundation; the National Natural Science Foundation of China, grant number 82003364; the Hunan Provincial Natural Science Foundation of China, grant number 2023JJ40827; the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University; and Karolinska Institutet.

Available from: 2023-10-16 Created: 2023-10-16 Last updated: 2023-10-31Bibliographically approved

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Parodis, Ioannis

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