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Increased Prevalence of Accidents and Injuries in Congenital Adrenal Hyperplasia: A Population-Based Cohort Study
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Pediatric Surgery, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
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2024 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 109, no 3, p. e1175-e1184Article in journal (Refereed) Published
Abstract [en]

CONTEXT: It has been suggested that injuries and accidents are increased in females with congenital adrenal hyperplasia (CAH), but the prevalence is unclear.

OBJECTIVE: To study the prevalence of injuries and accidents in females and males with CAH.

DESIGN, SETTING, AND PARTICIPANTS: Patients with CAH (n = 714, all 21-hydroxylase deficiency) were compared with matched controls (n = 71,400). Data were derived by linking National Population-Based Registers.

MAIN OUTCOME MEASURES: Prevalence of injuries and accidents.

RESULTS: Mean age was 29.8 ± 18.4 years. Injuries were more prevalent in patients with CAH than in controls (RR 1.34, 95%CI 1.24-1.44), and this was found in both sexes (females: 1.43, 1.29-1.58; males: 1.25, 1.12-1.38). In the classical phenotype, the prevalence of injuries was higher, especially in females but not in the non-classic phenotype. In the genotype groups, injuries were mainly increased in females. Head injuries were increased in all patients with CAH and in the different phenotypes and were mainly driven by females. More patients with CAH born before the introduction of neonatal screening had had an injury compared to controls (1.48, 1.35-1.62), this was seen in both sexes. In patients with CAH born after the introduction of screening, the prevalence of injuries was overall increased (1.20, 1.07-1.35), and in females with CAH but not in males. Accidents showed a similar pattern to injuries in all comparisons.

CONCLUSIONS: Patients with CAH had an increased prevalence of both injuries and accidents, especially in females and in those born before the neonatal screening program. Patients with NC phenotype were hardly affected.

Place, publisher, year, edition, pages
Oxford University Press, 2024. Vol. 109, no 3, p. e1175-e1184
Keywords [en]
21-hydroxylase deficiency, androgen concentrations, fall, trauma
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-109363DOI: 10.1210/clinem/dgad624ISI: 001094878300001PubMedID: 37862468Scopus ID: 2-s2.0-85195368216OAI: oai:DiVA.org:oru-109363DiVA, id: diva2:1806611
Available from: 2023-10-23 Created: 2023-10-23 Last updated: 2025-01-20Bibliographically approved

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