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Rare metastases diagnosed on 68Ga-DOTATOC-PET/CT in small intestinal and pancreatic NETs
Örebro University, School of Medical Sciences. Department of Surgery.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Surgery.ORCID iD: 0000-0003-4224-8912
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Surgery.
Faculty of Medicine and Health, Uppsala University, Uppsala, Sweden .
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2023 (English)In: Journal of neuroendocrinology, ISSN 0953-8194, E-ISSN 1365-2826, Vol. 35, no Suppl. 1, p. 116-116, article id D58Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Introduction: Neuroendocrine metastases to the orbita, heart, breast, bone, Virchow's lymph node, and pancreas are rarely encountered in small intestinal (SI-NETs) and pancreatic NETs (P-NETs).

Aim(s): We aimed to assessthe prevalence of rare metastatic locations in patients with well-differentiated SI-NETs and P-NETs, who had undergone 68Ga-DOTATOC-PET/CT at diagnosis and/or follow-up.

Materials and methods: In this retrospective analysis of 753 SI-NET patients and 418 P-NET patients treated at two tertiary referral centers, rare metastases were evident in 26.5% (310/1171) of the patient cohort.

Results: Among patients with rare metastases (n=310), 45 % were women and median age at metastases diagnosis was 70 years (43-90). Median Ki-67 was 7% (1-70); 106 were G1 tumors, 142 G2, 11 G3 and 51 of unknown grade. Rare metastatic sites were present in bone 18 % (215/1171), Virchow's lymph node 6 % (75/1171) and 4 % (42/1171) in the lung/pleura. Metastases to the pancreas, breast, heart and orbita were only encountered in SI-NET primaries with a frequency of 5 % (41/753), 2 % (17/753), 2 % (14/753) and 2 % (12/753) respectively. Concomitant liver metastases were present in 86 %. Uncommon metastases were more frequent in SI-NET as compared with P-NET primaries, 255/753 [34%] vs. 55/418 [13%], p ˂0.00001. Bone metastases were present in 23 % (175/753) of SI-NET and 10 % (40/418) of p-NET primaries.

Conclusion: In conclusion, rare metastases are more frequent in SI-NET than p-NETs. The variety and pattern of rare metastases seems different between SI-NETs and P-NET primaries, as orbita, heart, breast and Virchow's lymph node deposits were only encountered in SI-NETs patients; and bone metastases were approximately twice more often inthis group. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2023. Vol. 35, no Suppl. 1, p. 116-116, article id D58
Keywords [en]
neuroendocrine neoplasm, rare metastases, bone metastases, breast metastases, orbita metastases, heart metastases, lung and pleural metastases, pancreatic metastases
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-109401ISI: 001058866300102OAI: oai:DiVA.org:oru-109401DiVA, id: diva2:1807213
Conference
20th Annual ENETs Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease (ENETS 2023), Electronic Network, March 22-24, 2023
Available from: 2023-10-25 Created: 2023-10-25 Last updated: 2023-10-25Bibliographically approved

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Wedin, MariaDaskalakis, KosmasWallin, Göran

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