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The cascade of care for patients with chronic hepatitis delta in Southern Stockholm, Sweden for the past 30 years
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden; Centre for Bioinformatics and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
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2024 (English)In: Liver international, ISSN 1478-3223, E-ISSN 1478-3231, Vol. 44, no 1, p. 228-240Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND AIMS: Previous studies have shown suboptimal screening for hepatitis D virus (HDV) among patients with chronic hepatitis B (CHB). This study presents the cascade of care for HDV infection in a major secondary referral centre in Southern Stockholm, Sweden.

METHODS: HBsAg+ve patients attending Karolinska University Hospital (KUH) from 1992 to 2022 were identified. The prevalence of anti-HDV and/or HDV RNA positivity, interferon (IFN) therapy and maintained virological responses (MVR) after HDV treatment were assessed. Also, time to anti-HDV testing was analysed in relation to liver-related outcomes with logistic regression.

RESULTS: Among 4095 HBsAg+ve persons, 3703 (90.4%) underwent an anti-HDV screening; within a median of 1.8 months (range 0.0-57.1) after CHB diagnosis. This screening rate increased over time, to 97.9% in the last decade. Overall, 310 (8.4%) were anti-HDV+ve, of which 202 (65.2%) were HDV RNA+ve. Eighty-five (42%) received IFN, and 9 (10.6%) achieved MVR at the last follow-up. The predictive factors for anti-HDV screening were Asian origin, diagnosis after the year 2012, HIV co-infection (negative factor) and HBV DNA level < 2000 IU/mL in univariable analysis, while HIV co-infection was the only remaining factor in multivariable analysis. Delayed anti-HDV test >5 years was independently associated with worsened liver-related outcomes (adjusted odds ratio = 7.6, 95% CI 1.8-31.6).

CONCLUSION: Higher frequency of HDV screening than previously published data could be seen among CHB patients at KUH in a low-endemic setting. Receiving a delayed screening test seems to be associated with worse outcomes, stressing the need of a strategy for timely HDV diagnosis.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2024. Vol. 44, no 1, p. 228-240
Keywords [en]
HBV, HDV, HIV, cascade of care, hepatitis delta, screening
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Cancer and Oncology
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URN: urn:nbn:se:oru:diva-109511DOI: 10.1111/liv.15770ISI: 001094595000001PubMedID: 37904316Scopus ID: 2-s2.0-85175429815OAI: oai:DiVA.org:oru-109511DiVA, id: diva2:1808865
Available from: 2023-11-01 Created: 2023-11-01 Last updated: 2024-01-12Bibliographically approved

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Duberg, Ann-Sofi

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