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Temporal relationship of sleep apnea and acromegaly a nationwide study: a nationwide study
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID iD: 0000-0002-9501-6763
Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden.ORCID iD: 0000-0002-5306-1697
Department of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0002-1393-0421
Department of Molecular Medicine and Surgery, Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
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2018 (English)In: Endocrine, ISSN 1355-008X, E-ISSN 1559-0100, Vol. 62, no 2, p. 456-463Article in journal (Refereed) Published
Abstract [en]

Purpose: Patients with acromegaly have an increased risk of sleep apnea, but reported prevalence rates vary largely. Here we aimed to evaluate the sleep apnea prevalence in a large national cohort of patients with acromegaly, to examine possible risk factors, and to assess the proportion of patients diagnosed with sleep apnea prior to acromegaly diagnosis.

Methods: Cross-sectional multicenter study of 259 Swedish patients with acromegaly. At patients' follow-up visits at the endocrine outpatient clinics of all seven university hospitals in Sweden, questionnaires were completed to assess previous sleep apnea diagnosis and treatment, cardiovascular diseases, smoking habits, anthropometric data, and S-IGF-1 levels. Daytime sleepiness was evaluated using the Epworth Sleepiness Scale. Patients suspected to have undiagnosed sleep apnea were referred for sleep apnea investigations.

Results: Of the 259 participants, 75 (29%) were diagnosed with sleep apnea before the study start. In 43 (57%) of these patients, sleep apnea had been diagnosed before the diagnosis of acromegaly. After clinical assessment and sleep studies, sleep apnea was diagnosed in an additional 20 patients, yielding a total sleep apnea prevalence of 37%. Higher sleep apnea risk was associated with higher BMI, waist circumference, and index finger circumference. Sleep apnea was more frequent among patients with S-IGF-1 levels in the highest quartile.

Conclusion: Sleep apnea is common among patients with acromegaly, and is often diagnosed prior to their acromegaly diagnosis. These results support early screening for sleep apnea in patients with acromegaly and awareness for acromegaly in patients with sleep apnea.

Place, publisher, year, edition, pages
Springer, 2018. Vol. 62, no 2, p. 456-463
Keywords [en]
Acromegaly, comorbidities, risk factors, sleep apnea
National Category
Medical and Health Sciences Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-109719DOI: 10.1007/s12020-018-1694-1ISI: :000449306400022PubMedID: 30066288Scopus ID: 2-s2.0-85052066042OAI: oai:DiVA.org:oru-109719DiVA, id: diva2:1811744
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Umeå UniversityRegion VästernorrlandAvailable from: 2023-11-14 Created: 2023-11-14 Last updated: 2023-11-17Bibliographically approved

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Wahlberg, Jeanette

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Vouzouneraki, KonstantinaFranklin, Karl A.Forsgren, MariaDahlgren, ChristinaBurman, PiaErfurth, Eva-MarieWahlberg, JeanetteÅkerman, Anna-KarinRagnarsson, OskarDahlqvist, Per
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Endocrine
Medical and Health SciencesEndocrinology and Diabetes

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