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Relative handgrip strength correlates inversely with increased body fat, inflammatory markers and increased serum lipids in young, healthy adults: The LBA study
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden; Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.ORCID iD: 0000-0001-8458-6448
Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.
The Biomedical Platform, Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Jönköping, Sweden.
2024 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 207, article id 111057Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Handgrip strength (HGS) is a surrogate marker of whole body strength that has been observed correlate inversely with the metabolic syndrome (MetS). In this study, we examined whether HGS in young, healthy individuals, was associated with surrogate endpoints of the MetS. A secondary goal was to examine whether absolute HGS (absHGS) or relative HGS (relHGS) was a stronger predictor of MetS.

METHOD: 834 subjects (577 women), aged 18-26, were recruited. Surrogate endpoints for MetS were waist circumference, HDL, fasting glucose, fasting insulin, triglycerides, and systolic and diastolic blood pressure (BP). We also examined the association between HGS and body fat percentage, HOMA-IR, CRP, orosomucoid and apolipoprotein A-1 and apolipoprotein B. The associations were examined using linear regression.

RESULTS: AbsHGS and relHGS were each associated with several surrogate endpoints of the metabolic syndrome, with RelHGS being statistically significantly associated with a greater number of the variables - all except fasting glucose and diastolic BP.

CONCLUSION: RelHGS correlates with components of the MetS even in young, healthy populations. It is a better predictor of MetS components than absHGS. As a cheap and easy to use biomarker, relHGS holds merit as a screening tool for metabolic dysfunction even in preclinical contexts.

Place, publisher, year, edition, pages
Elsevier, 2024. Vol. 207, article id 111057
Keywords [en]
ApoA1, CRP, Relative handgrip strength, fasting serum insulin, metabolic syndrome, orosomucoid, young adults
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-110463DOI: 10.1016/j.diabres.2023.111057ISI: 001147331300001PubMedID: 38104901Scopus ID: 2-s2.0-85180295607OAI: oai:DiVA.org:oru-110463DiVA, id: diva2:1821713
Funder
Region Örebro County, OLL-780061Nyckelfonden, OLL-787681Umeå University, RV-865861Afa Sjukförsäkringsaktiebolag, 130275Available from: 2023-12-20 Created: 2023-12-20 Last updated: 2024-02-08Bibliographically approved

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Pettersson-Pablo, Paul

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