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An individual participant data meta-analysis of psychological interventions for preventing depression relapse
Department of Psychiatry, Amsterdam Public Health (APH), Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.ORCID iD: 0000-0003-1864-1861
Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; WHO Collaborating Centre for Research and Dissemination of Psychological Interventions, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Department of Health and Community Sciences, University of Exeter, Exeter, UK.
Department of Psychiatry, Amsterdam Public Health (APH), Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands.
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2024 (English)In: Nature Mental Health, E-ISSN 2731-6076, Vol. 2, no 2, p. 154-163Article in journal (Refereed) Published
Abstract [en]

Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.

Place, publisher, year, edition, pages
Springer Nature, 2024. Vol. 2, no 2, p. 154-163
Keywords [en]
Depression, relapse prevention
National Category
Psychiatry
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-111886DOI: 10.1038/s44220-023-00178-xISI: 001390819900001OAI: oai:DiVA.org:oru-111886DiVA, id: diva2:1840498
Note

 This project was funded in part by internal funds fromthe Alliance for Public Health at the Amsterdam University MedicalCentre—Mental Health Stream.

Available from: 2024-02-23 Created: 2024-02-23 Last updated: 2025-01-14Bibliographically approved

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Holländare, Fredrik

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