This paper considers the unfolding of Smart Specialisation Strategy (RIS3) in one of Europe's innovation-leading metropolitan regions: Stockholm, Sweden. Theoretically, it contributes to debates around change agency and reflects more broadly, which implications arise for metropolitan innovation-leader regions and which are of more generic nature. It argues that actor endowments, dense networks, experience with participatory governance processes and good governance are not sufficient for a successful implementation of RIS3. It finds that transformative regional innovation policy is contingent upon the adequate empowerment of change agents rather than on general regional preconditions.