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Occurrence of mucosa-affecting diseases of the upper airways in middle ear cholesteatoma patients: a nationwide case-control study
Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Medical Unit of ENT, Hearing and Balance, Karolinska University Hospital, Stockholm, Sweden.
Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Medical Unit of ENT, Hearing and Balance, Karolinska University Hospital, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Otolaryngology, Västerås Hospital, Västerås, Sweden; Region Västmanland, Centre for Clinical Research, Uppsala University, Västmanland Hospital, Västerås, Sweden.
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2024 (English)In: European Archives of Oto-Rhino-Laryngology, ISSN 0937-4477, E-ISSN 1434-4726, Vol. 281, no 8, p. 4081-4087Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Exploring a possible link between upper airway inflammation and the development of cholesteatoma by studying the association between mucosa-affecting diseases of the upper airways and cholesteatoma surgery.

METHODS: This is a nationwide case-control study of 10,618 patients who underwent surgery for cholesteatoma in Sweden between 1987 and 2018. The cases were identified in the National Patient Register and 21,235 controls matched by age, sex and place of residency were included from national population registers. Odds ratios (OR) and corresponding 95% confidence intervals were used to assess the association between six types of mucosa-affecting diseases of the upper airways and cholesteatoma surgery.

RESULTS: Chronic rhinitis, chronic sinusitis and nasal polyposis were more common in cholesteatoma patients than in controls (OR 1.5 to 2.5) as were both adenoid and tonsil surgery (OR > 4) where the strongest association was seen for adenoid surgery. No association was seen between allergic rhinitis and cholesteatoma.

CONCLUSION: This study supports an association between mucosa-affecting diseases of the upper airways and cholesteatoma. Future studies should aim to investigate the mechanisms connecting mucosa-affecting diseases of the upper airways and cholesteatoma formation regarding genetic, anatomical, inflammatory and mucosa properties.

Place, publisher, year, edition, pages
Springer, 2024. Vol. 281, no 8, p. 4081-4087
Keywords [en]
Adenoidectomy, Cholesteatoma, Nasal polyposis, Rhinitis, Sinusitis, Tonsillectomy
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:oru:diva-112557DOI: 10.1007/s00405-024-08567-3ISI: 001190284300002PubMedID: 38517544Scopus ID: 2-s2.0-85188447783OAI: oai:DiVA.org:oru-112557DiVA, id: diva2:1846721
Funder
Karolinska Institute
Note

Open access funding provided by Karolinska Institute. Grants from The Center for Innovative Medicine (FoUI-975599), ALF (FoUI-955027), the re(HFF19-0016) and ACTA Otolaryngologica.

Available from: 2024-03-25 Created: 2024-03-25 Last updated: 2024-09-02Bibliographically approved

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