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The Neuroblastoma Microenvironment, Heterogeneity and Immunotherapeutic Approaches
Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, 11883 Stockholm, Sweden.
Örebro University, School of Medical Sciences. Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, 11883 Stockholm, Sweden.
Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, 11883 Stockholm, Sweden.
2024 (English)In: Cancers, ISSN 2072-6694, Vol. 16, no 10, article id 1863Article, review/survey (Refereed) Published
Abstract [en]

Neuroblastoma is a peripheral nervous system tumor that almost exclusively occurs in young children. Although intensified treatment modalities have led to increased patient survival, the prognosis for patients with high-risk disease is still around 50%, signifying neuroblastoma as a leading cause of cancer-related deaths in children. Neuroblastoma is an embryonal tumor and is shaped by its origin from cells within the neural crest. Hence, neuroblastoma usually presents with a low mutational burden and is, in the majority of cases, driven by epigenetically deregulated transcription networks. The recent development of Omic techniques has given us detailed knowledge of neuroblastoma evolution, heterogeneity, and plasticity, as well as intra- and intercellular molecular communication networks within the neuroblastoma microenvironment. Here, we discuss the potential of these recent discoveries with emphasis on new treatment modalities, including immunotherapies which hold promise for better future treatment regimens.

Place, publisher, year, edition, pages
MDPI, 2024. Vol. 16, no 10, article id 1863
Keywords [en]
Immunotherapy, neural crest, neuroblastoma, tumor microenvironment
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-113869DOI: 10.3390/cancers16101863ISI: 001232657600001PubMedID: 38791942Scopus ID: 2-s2.0-85194361798OAI: oai:DiVA.org:oru-113869DiVA, id: diva2:1860887
Funder
Swedish Cancer Society, 21 1556Swedish Childhood Cancer Foundation, PR2020-0140King Gustaf V Jubilee Fund, 154048Available from: 2024-05-27 Created: 2024-05-27 Last updated: 2024-06-11Bibliographically approved

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Bedoya Reina, Oscar

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