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Surgery for primary ventral hernias and risk of postoperative pain, nausea: a population-based register study
Faculty of Medicine and Health, Department of Surgery, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-2090-4563
Faculty of Medicine and Health, Department of Surgery, Örebro University Hospital, Örebro, Sweden.
Division of Anesthesiology and Intensive Care, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, Huddinge, Sweden.
Department of Surgery, Skane University Hospital, Malmö, Sweden; Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
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2025 (English)In: Hernia, ISSN 1265-4906, E-ISSN 1248-9204, Vol. 29, no 1, article id 68Article in journal (Refereed) Published
Abstract [en]

PURPOSE: The aim of this study was to evaluate risk factors for postoperative pain and nausea after open repair for primary ventral hernias.

METHOD: A population-based registry study was conducted based on data assembled from the Swedish national ventral hernia repair register between January 2016 and December 2021and cross-matched with the Swedish perioperative register.

RESULTS: Altogether 2064 open ventral hernia repairs were registered, including 816 (39.5%) performed on women. Of these, 91 (4.4%) were registered to suffer postoperative nausea or vomiting (PONV) and 403 (19.5%) postoperative pain (PP). In both univariable and multivariable logistic regression analyses, significant predictors of postoperative nausea and pain included male gender, which was associated with lower odds of both postoperative nausea (multivariable OR: 0.30, 95% CI: 0.18-0.49, P < 0.001) and postoperative pain (multivariable OR: 0.60, 95% CI: 0.44-0.83, P = 0.002). Additional predictors of postoperative nausea included emergency surgery (multivariable OR: 4.08, 95% CI: 1.10-15.08, P = 0.035), operative time > 40 min (multivariable OR: 4.15, 95% CI: 2.24-7.69, P < 0.001). Conversely total intravenous anesthesia was associated with lower incidence of PONV (multivariable OR: 0.40, 95% CI: 0.22-0.74, P = 0.003). Other factors, such as age, BMI, smoking status, ASA classification, hernia size, surgery type, operative time, and anesthesia type, were not significantly associated with postoperative pain after adjusting for other variables.

CONCLUSION: Postoperative nausea and vomiting (PONV) are significantly reduced with total intravenous anesthesia (TIVA) compared to inhalation anesthesia, with no notable difference in postoperative pain between the two methods.

Place, publisher, year, edition, pages
Springer Nature, 2025. Vol. 29, no 1, article id 68
Keywords [en]
General anesthesia, Inhalation anesthesia, Postoperative pain and nausea/vomiting, Primary ventral hernia, Umbilical hernia
National Category
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-119682DOI: 10.1007/s10029-025-03256-4ISI: 001398035000001PubMedID: 39812906OAI: oai:DiVA.org:oru-119682DiVA, id: diva2:1942461
Available from: 2025-03-05 Created: 2025-03-05 Last updated: 2025-03-05Bibliographically approved
In thesis
1. Laparoscopic ventral hernia repair with intraperitoneal onlay mesh
Open this publication in new window or tab >>Laparoscopic ventral hernia repair with intraperitoneal onlay mesh
2025 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Advancements in technology and medicine have rendered laparoscopic ventral hernia repair (LVHR) more favourable than open ventral hernia repair (OVHR). Albeit associated with risk of postoperative seroma, LVHR may reduce wound infection rates and hospital stays. However, LVHR requires accurate technique and careful patient selection.

Study I was a retrospective study conducted at the Karlskoga Hospital Hernia Centre. From January 2017 to June 2020, 876 ventral hernia operations were performed. We analysed 213 patients who underwent ventral hernia repair with Intraperitoneal Onlay Mesh without defect closure (sIPOM), IPOM with defect closure (IPOM-P), and IPOM with peritoneal bridging (IPOM-pb) and compared the incidence of postoperative seroma, discomfort, recurrence, and complications.

Study II was a randomized controlled trial with 112 participants who underwent laparoscopic ventral hernia repair between November 2018 and December 2020. The participants underwent ultrasonography at 1, 3, 6 and 12 months postoperatively. Postoperative seroma, discomfort, and complications following IPOMpb and sIPOM were analysed.

Study III was a registry-based study of the impact of COVID-19 on emergency and planned hernia repair procedures, divided into two periods; the pre non COVID-19 Period Januari 2016 - December 2019 as a control group and the COVID-19 Period Januari 2020 to December 2021 as the study group.

Study IV was a population-register study based on a retrospective cohort evaluating risk factors for postoperative pain, nausea and vomiting in 4795 patients who underwent ventral hernia repair between 2016 and 2021, with 2409 of them undergoing open ventral hernia repair surgery. Data were assembled from the Swedish ventral hernia register and Swedish perioperative register.

Study I showed that the IPOM-pb approach was as safe and feasible as conventional IPOM, requiring no additional effort from the surgeon or staff.

Study II showed lower incidence of postoperative seroma and discomfort in IPOM with peritoneal bridging in early-stage follow-ups, with no significant difference in subsequent follow-ups.

In study III the pandemic planned surgeries were impacted but the result in this study showed that there was no increase in emergency hernia operations due to delayed planned surgery. Careful observation and caution are crucial during a pandemic.

Study IV showed that postoperative pain, nausea and vomiting are more common in women, emergency surgery, younger age patients, and those who had surgery with inhalation anesthesia compared to total intravenous anesthesia.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2025. p. 73
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 301
Keywords
Laparoscopic hernia surgery, Ventral hernia, IPOM
National Category
Surgery
Identifiers
urn:nbn:se:oru:diva-116581 (URN)9789175295909 (ISBN)9789175295916 (ISBN)
Public defence
2025-03-28, Örebro universitet, Campus USÖ, Hörsal X1, Södra Grev Rosengatan 32, Örebro, 09:00 (English)
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Supervisors
Available from: 2024-10-08 Created: 2024-10-08 Last updated: 2025-04-02Bibliographically approved

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