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Prophylactic inguinal-femoral irradiation as an alternative to primary lymphadenectomy in treatment of vulvar carcinoma
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0002-5063-631X
2007 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 31, no 5, 1077-1085 p.Article in journal (Refereed) Published
Abstract [en]

In a complete geographic series of 294 cases of primary vulvar carcinomas prophylactic inguinal-femoral irradiation was used as a standard postoperative therapy. Inguinal lymph node dissection was performed in only 27 cases (9%) and was not part of the standard surgery. The histology was squamous cell carcinoma in 269 cases (92%). The primary surgery was total vulvectomy, partial vulvectomy, or local resection of the tumor. The main type of radiotherapy was adjuvant inguinal irradiation. Two separate, symmetrical and rectangular inguinal fields were irradiated with combined photon and electron beams. In the complete series 127 recurrences (43%) were recorded. Local (24%) and regional recurrences (19%) were most frequent. Type of surgery was not associated with the risk of tumor recurrence. The 5-year overall survival rate was 53% and the relapse-free survival (RFS) rate was 55%. Tumor grade was significantly (P=0.007) associated with the RFS. The inguinal RFS rate was 75% both for patients treated with adjuvant inguinal irradiation without lymphadenectomy and patients treated with primary lymph adenectomy +/- inguinal irradiation. Postoperative complications were recorded in 22%. Postoperative complications occurred most frequently in the subgroup undergoing inguinal lymphadenectomy. Chronic lymph edemas were the most serious late tissue reactions.

Place, publisher, year, edition, pages
Athens, Greece: Lychnia , 2007. Vol. 31, no 5, 1077-1085 p.
Keyword [en]
Prophylactic irradiation, lymphadenectomy, vulvar carcinoma
National Category
Medical and Health Sciences Cancer and Oncology
Research subject
Cancer Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-6059PubMedID: 17912433OAI: oai:DiVA.org:oru-6059DiVA: diva2:208661
Available from: 2009-03-19 Created: 2009-03-19 Last updated: 2016-12-12Bibliographically approved

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