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Prophylactic pelvic irradiation as part of primary therapy in uterine sarcomas
Örebro University, School of Health and Medical Sciences.ORCID iD: 0000-0002-5063-631X
2008 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 32, no 5, p. 1111-1117Article in journal (Refereed) Published
Abstract [en]

In a complete geographic series of 155 cases of primary uterine sarcomas, prophylactic pelvic irradiation was used as standard postoperative therapy in the majority of the cases. Vaginal brachytherapy was also added as a boost. The histology was leiomyosarcoma in 62 cases (40%), carcinosarcoma in 60 (39%), endometrial stromal sarcoma in 25 (16%), and other types in 8 cases (5%). The primary surgery was extended hysterectomy in 11 cases (7%), simple hysterectomy in 110 (71%), and supravaginal hysterectomy in 12 (8%). In 22 cases (14%) no major surgery was possible. In the complete series, 62 recurrences (40%) were recorded. Local (9%), regional (9%), and distant recurrences (28%) were the most frequent. The type of surgery was associated with the risk of tumor recurrence. Extended surgery reduced the risk of local and regional recurrences. The 5-year overall survival rate was 42% and the recurrence-free survival (RFS) was 37%. The number of mitoses was significantly (P=0.007) associated with survival. The locoregional RFS rate was 75% for patients treated with adjuvant irradiation and 83% for patients treated with primary surgery alone. Serious late tissue reactions from the bladder and intestine occurred in 7% of the irradiated cases. The locoregional tumor control rate was high in this series of patients, but no significant difference was found between patients treated with surgery alone and surgery plus postoperative pelvic irradiation. This was true for all histological subtypes of the uterine sarcomas. However, this was not a randomized study and selection bias cannot be ruled out

Place, publisher, year, edition, pages
2008. Vol. 32, no 5, p. 1111-1117
Keyword [en]
Prophylactic pelvic irradiation, uterine sarcomas
National Category
Medical and Health Sciences
Research subject
Cancer Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-6064PubMedID: 18425339OAI: oai:DiVA.org:oru-6064DiVA, id: diva2:208676
Available from: 2009-03-19 Created: 2009-03-19 Last updated: 2017-12-13Bibliographically approved

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Sorbe, Bengt

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