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Predicting and monitoring colitis development in mice by micro-computed tomography
Astra-Zeneca, Mölndal.
Astra-Zeneca, Mölndal.
Astra-Zeneca, Mölndal.
Astra-Zeneca, Mölndal.
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2008 (English)In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 14, no 4, 491-499 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Computed tomography (CT) has been developed as a tool for monitoring human inflammatory bowel disease (IBD). The aim of this study was to evaluate colon wall thickness as a noninvasive marker in the dextran sodium sulfate (DSS) mouse model of colitis using micro-CT. METHODS: Mice were examined by micro-CT 1, 2, or 4 times between day 0 (d0) and d26 after induction of colitis to document the kinetics of changes in colon wall thickness and its relation to colitis development. RESULTS: DSS-treated mice displayed a significantly thicker colon wall at all timepoints (days 5, 8, 12, 19, and 26) investigated compared to healthy controls. Colon wall thickness showed a good correlation to the macroscopic grading of colitis (r = 0.81). The increase in colon wall thickness occurred mainly during the acute phase of colitis (between days 5 and 12) and did not progress much further in the chronic phase of colitis (d26). Colon wall thickness at d26 was thereby predicted by measurements at d12. All mice did not respond equally to DSS and this difference was manifest during the first 2 weeks of colitis, providing an important tool in stratifying responders from nonresponders. CONCLUSIONS: While the potential impact of handling and anesthesia should be considered on repeated micro-CT, irradiation exposure during repeated micro-CT did not affect the development of colitis. Thus, the results suggest that micro-CT can be used for monitoring and prediction of the inflammatory response in mouse colitis in future therapeutic studies.

Place, publisher, year, edition, pages
2008. Vol. 14, no 4, 491-499 p.
National Category
Medical and Health Sciences Gastroenterology and Hepatology Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-6104DOI: 10.1002/ibd.20343PubMedID: 18161841OAI: oai:DiVA.org:oru-6104DiVA: diva2:209464
Available from: 2009-03-25 Created: 2009-03-25 Last updated: 2016-12-06Bibliographically approved

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