oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention
Clinical Nutrition and Metabolism, Department of Public health and Caring sciences, Uppsala University, Sweden.
Clinical Nutrition and Metabolism, Department of Public health and Caring sciences, Uppsala University, Sweden.
Örebro University, School of Hospitality, Culinary Arts & Meal Science.
Clinical Nutrition and Metabolism, Department of Public health and Caring sciences, Uppsala University, Sweden.
Show others and affiliations
2008 (English)In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 18, no 10, p. 683-690Article in journal (Refereed) Published
Abstract [en]

Background and aims

Direct measurement of desaturase activities are difficult to obtain in humans. Consequently, surrogate measures of desaturase activity (estimated desaturase activities) have been frequently used in observational studies, and estimated Δ9- (or stearoyl-CoA-desaturase (SCD)), Δ6- and Δ5-desaturase activities have been associated with cardiometabolic disease. Data on how the markers of desaturase activities are modified by changes in dietary fat quality are lacking and therefore warrant examination.

Methods and results

In a two-period (three weeks) strictly controlled cross-over study, 20 subjects (six women and 14 men) consumed a diet high in saturated fat (SAT-diet) and a rapeseed oil diet (RO-diet), rich in oleic acid (OA), linoleic acid (LA) and α-linolenic acid (ALA). Estimated desaturase activities were calculated as precursor to product FA ratios in serum cholesteryl esters and phospholipids. The estimated SCD [16:1 n-7/16:0] and Δ6-desaturase [20:3 n-6/18:2 n-6] was significantly higher while Δ5-desaturase [20:4 n-6/20:3 n-6] was significantly lower in the SAT-diet (P < 0.001 for all), compared to the RO-diet. The serum proportions of palmitic, stearic, palmitoleic and dihomo-γ-linolenic acids were significantly higher in the SAT-diet while the proportions of LA and ALA were significantly higher in the RO-diet.

Conclusion

This is the first study to demonstrate that surrogate measures of desaturase activities change as a consequence of an alteration in dietary fat quality. Both the [16:1/16:0]-ratio and 16:1 seem to reflect changes in saturated fat intake and may be useful markers of saturated fat intake in Western countries.

Place, publisher, year, edition, pages
Amsterdam: Elsevier , 2008. Vol. 18, no 10, p. 683-690
National Category
Cardiac and Cardiovascular Systems
Research subject
Internal Medicine
Identifiers
URN: urn:nbn:se:oru:diva-6141DOI: 10.1016/j.numecd.2007.11.002OAI: oai:DiVA.org:oru-6141DiVA, id: diva2:209881
Available from: 2009-03-27 Created: 2009-03-27 Last updated: 2017-12-13Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Gustafsson, Inga-Britt

Search in DiVA

By author/editor
Gustafsson, Inga-Britt
By organisation
School of Hospitality, Culinary Arts & Meal Science
In the same journal
NMCD. Nutrition Metabolism and Cardiovascular Diseases
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 147 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf