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Skeletal muscle morphology in power-lifters with and without anabolic steroids
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (RISPA- MEP-RG)ORCID iD: 0000-0002-9831-0896
2005 (English)In: Histochemistry and Cell Biology, ISSN 0948-6143, E-ISSN 1432-119X, Vol. 124, no 2, 167-175 p.Article in journal (Refereed) Published
Abstract [en]

The morphological appearance of the vastus lateralis (VL) muscle from high-level power-lifters on long-term anabolic steroid supplementation (PAS) and power-lifters never taking anabolic steroids (P) was compared. The effects of long- and short-term supplementation were compared. Enzyme-immunohistochemical investigations were performed to assess muscle fiber type composition, fiber area, number of myonuclei per fiber, internal myonuclei, myonuclear domains and proportion of satellite cells. The PAS group had larger type I, IIA, IIAB and IIC fiber areas (p<0.05). The number of myonuclei/fiber and the proportion of central nuclei were significantly higher in the PAS group (p<0.05). Similar results were seen in the trapezius muscle (T) but additionally, in T the proportion of fibers expressing developmental myosin isoforms was higher in the PAS group compared to the P group. Further, in VL, the PAS group had significantly larger nuclear domains in fibers containing > or = 5 myonuclei. The results of AS on VL morphology in this study were similar to previously reported short-term effects of AS on VL. The initial effects from AS appear to be maintained for several years.

Place, publisher, year, edition, pages
2005. Vol. 124, no 2, 167-175 p.
National Category
Medical and Health Sciences Physiology Social Sciences Interdisciplinary Sport and Fitness Sciences
Research subject
Sports Science; Physiology
Identifiers
URN: urn:nbn:se:oru:diva-6276DOI: 10.1007/s00418-005-0029-5PubMedID: 16059740OAI: oai:DiVA.org:oru-6276DiVA: diva2:211702
Available from: 2009-04-17 Created: 2009-04-17 Last updated: 2016-12-07Bibliographically approved

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Kadi, Fawzi
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CiteExportLink to record
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Citation style
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